PPARs and the complex journey to obesity

By R. Evans, G. Barish, Yong-Xu Wang. Nature Medicine, 2004

1,705 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/bdff344a1b12ddce1db26dbec26ab288cc606b61

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Citations in the corpus

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review (2014, background): “PPARa is highly expressed in muscles, liver, heart, and kidney, and mainly regulates genes involved in the metabolism of lipids and lipoproteins [20,25–27].”
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “LXRa and PPARg sense the fed state by responding to dietary cholesterol and fat, promoting the effects of insulin, and facilitating the storage of fat as a fuel source (Chawla et al., 2001; Evans et al., 2004; Kalaany et al., 2005).”
Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. (2006, background): “Remarkably similar pathological features of alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH) make it generally difficult to distinguish AFLD from NAFLD on morphological grounds alone despite the distinctions implied by these etiological designations (2, 6, 8).”
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. (2008, background): “, 2001), control systemic fatty acid metabolism by transcriptional activation of target genes (Evans et al., 2004; Kliewer et al., 2001).”
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006, background): “Their activities are likely to be influenced by their binding specificities toward the different PPARs and by cell, tissue, or organ-specific effects (Bishop-Bailey and Wray, 2003; Des-vergne et al., 2004; Evans et al., 2004).”
Peroxisome Proliferator-Activated Receptor Alpha Target Genes (2010, background): “The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the superfamily of nuclear hormone receptors and play an important role in nutrient homeostasis [1–3].”
PPARγ signaling and metabolism: the good, the bad and the future (2013, background): “HFD, ligands or TZDs (1) activate PPARγ-RXR functional heterodimers (2) and maintain”
Dietary fats and prevention of type 2 diabetes (2008, background): “Impaired insulin action has been closely linked to CLA-induced lipid peroxidation and inflammation [67], but other mechanisms, such as ectopic fat accumulation and downregulation of peroxisome proliferator activating receptors (PPARs) may also be involved.”
The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases (2011, background): “PPAR-γ is further subdivided in four isoforms.[4] • γ1 - expressed in virtually all tissues, including heart, muscle, colon, kidney, pancreas, and spleen.”