The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases
By S. Tyagi, Paras Gupta, Arminder Singh Saini, Chaitnya Kaushal, Saurabh Sharma. Journal of Advanced Pharmaceutical Technology & Research, 2011
906 citations recorded by the source corpus.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism. Thus, PPAR family of nuclear receptors plays a major regulatory role in energy homeostasis and metabolic function. The present review critically analyzes the protective and detrimental effect of PPAR agonists in dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, fertility or reproduction, pain, and obesity.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/7e27ea6d289c6c5a33365efb26e0cb4c8fb58c77
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Citations in the corpus
- Targeting cancer stem cell pathways for cancer therapy (2020, background): “382 In recent years, studies have found that PPARs are closely related to energy (lipid and sugar) metabolism, cell differentiation, proliferation, apoptosis, and inflammatory reactions.”
- Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels (2019, background): “PPAR γ is a nuclear hormone receptor which is expressed mainly in the adipose tissue [30].”