The DNA methyltransferases of mammals.

By T. Bestor. Human Molecular Genetics, 2000

2,131 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bd69807ee32352c2648a4ff5697dba7ba8737f22

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In Genetics

1. Hao Wu
2. Wolf Reik
3. A. Bird
4. S. Baylin
5. W. Dean
6. Jian‐Kang Zhu
7. Alexander Meissner
8. François Fuks

In Molecular Biology

1. Hao Wu
2. Manel Esteller
3. S. Baylin
4. Peter A. Jones
5. Yi Zhang
6. Wolf Reik
7. A. Bird
8. Alexander Meissner

Citations in the corpus

• DNA hypomethylation and human diseases. (2007, background): “These established patterns are then precisely transmitted via mitosis and in differentiated cells are maintained after DNA replication [117].”
• Epigenetic reprogramming in mammals. (2005, background): “Indeed, Dnmt1 protein inherited from the oocyte (Dnmt1o) is seemingly excluded from the nucleus during the first three cleavage divisions (51,52) accounting for the loss of methylation by a passive mechanism.”
• Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer (2007, background): “Whereas the global DNA methylation pattern established at the time of implantation is thought to be maintained at each cell division by the action of DNA (cytosine-5-)-methyltransferase 1 (DNMT1) at the replication for”
• Epigenetics and Colorectal Cancer (2011, background): “Overview of DNA methylation DNA methylation refers to the enzymatic addition of a methyl group to the 5′-position of cytosine by DNA methyltransferases (DNMTs) to produce 5-methylcytosine, a normal base in DNA”
• Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. (2007, background): “DNA methylation occurs predominantly at CpG sites in the mammalian genome (Jones & Takai, 2001) by the DNA methyltransferase (DNMT) enzymes (Bestor, 2000; Rountree et al., 2001).”
• Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse (2003, background): “…of IAPs to Methylation Reprogramming May Provide a Mechanism for Epigenetic Inheritance in the Mouse Natasha Lane,1 Wendy Dean,1 Sylvia Erhardt,2 Petra Hajkova,3 Azim Surani,2 Jörn Walter,3 and Wolf Reik1* 1Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge,…”
• The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. (2003, background): “Methylation of CpG dinucleotides in mammals is carried out by three active DNA methyltransferases, Dnmt1, Dnmt3a and Dnmt3b ( 2 ).”
• Highly integrated single-base resolution maps of the epigenome in Arabidopsis. (2008, positive): “In higher eukaryotes, DNA methylation is involved in myriad essential processes, including embryogenesis, genomic imprinting, and tumorigenesis in mammals, and in transposon silencing and gene regulation in plants (Bestor, 2000; Li et al., 1992; Lippman et al., 2004; Rhee et al., 2002; Zhang et al.,”
• Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003, background): “Mechanistic insights into the role of DNA methylation and the establishment of methylation patterns during development have come from phenotypic analyses of mice with mutations in the various DNA methyltransferase (DNMT) genes ( Table 1”
• Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia (2011, background): “In DNMT3A , encoding a member of the DNA methyltransferase 3 famil”