Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

By Xiao-jing Yan, Jie Xu, Zhao-hui Gu, Chun-ming Pan, G. Lu, Yang Shen, Jing-yi Shi, Yong-mei Zhu, L. Tang, Xiao-Wei Zhang and 6 more. Nature Genetics, 2011

815 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bf9d28fdd83d24750fbc4c8e9c956ab3fff0f01c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Hao Wu
2. Peter A. Jones
3. Christoph Bock
4. S. Baylin
5. J. You

In Hematology

1. Yi Zhang
2. Hao Wu
3. Peter A. Jones
4. Margaret A. Goodell
5. S. Baylin

In Molecular Biology

1. Peter A. Jones
2. S. Baylin
3. Hao Wu
4. Christoph Bock
5. Yi Zhang
6. J. You
7. Berthold Göttgens
8. H. Gu

Citations in the corpus

• The role of mutations in epigenetic regulators in myeloid malignancies (2012, background): “Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).”
• Epigenetic Determinants of Cancer. (2016, background): “…(Kanai et al. 2003) Overexpression (Wu et al. 2007) DNMT3A DNA methyltransferase MDS; AML Mutation (Ley et al. 2010; Yamashita et al. 2010; Yan et al. 2011) DNMT3B DNA methyltransferase ICF syndrome, SNPs in breast and lung adenoma Mutation (Wijmenga et al. 2000) Mutation (Shen et al.…”
• Cancer Genetics and Epigenetics: Two Sides of the Same Coin? (2012, background): “All known DNMT3A mutations are related to poor survival in AML (Ley et al., 2010; Yan et al., 2011), suggesting that these mutations prevent differentiation and have an important role in the progression of disease.”
• Maftools: efficient and comprehensive analysis of somatic variants in cancer (2018, neutral): “5E; Yan et al. 2011).”
• Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “The founding member of the Tet family of DNA hydroxylases, the TET1 gene, was initially identified in acute myeloid leukemia (AML) as a fusion partner of the histone H3 Lys 4 (H3K4) methyltransferase MLL (mixed-lineage leukemia) (Ono et al. 2002; Lorsbach et al. 2003).”
• Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal (2014, background): “Finally, we showed that the edges of DNA methylation canyons are highly dynamic in a manner concordant with loss of Dnmt3a function (Jeong et al., 2014; Challen et al., 2012), the mutation of which is associated with hematologic malignancies (Ley et al., 2010; Yan et al., 2011).”