The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase.

By François Fuks, P. J. Hurd, Rachel Deplus, Tony Kouzarides. Nucleic Acids Research, 2003

787 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/43a078ee457fb65ba2e7d67031fc0860f45bba17

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Citations in the corpus

DNA methylation: The nuts and bolts of repression (2007, background): “DNAmethyltransferases have been shown to interactwith the histone methyltransferases SUV39, which is responsible for methylation of H3K9, and EZH2, which catalyzes H3K27 methylation (Fuks et al., 2003; Vire et al., 2006).”
Distinct Epigenomic Landscapes of Pluripotent and Lineage-committed Human Cells (2010, background): “There is also evidence that some crosstalk between these epigenetic mechanisms exists, suggesting a direct link between H3K9 methyltransferases (HKMT) and DNA methyltransferases (DNMTs) (Fuks et al., 2003; Jackson et al., 2002; Lehnertz et al., 2003; Li et al., 2006; Tamaru and Selker, 2001).”
DNA methylation and histone modifications: teaming up to silence genes. (2005, background): “In mammals, DNA methyltransferases interact with Suv39h H3K9 methyltransferases [10 ,11], and loss of H3K9 methylation in Suv39h-knockout embryonic stem cells decreases Dnmt3b-dependent CpG methylation at major centromeric satellites [10 ].”
Epigenetic Determinants of Cancer. (2016, background): “…enzymes, such as methyltransferases (KMTs) and demethylases (KDMs) are key for the recruitment of, or being recruited by, DNMTs, as elaborated in Figure 7 and Section 2.2.2 of Almouzni and Cedar (2014) (Di Croce et al. 2002; Fuks et al. 2003; Brenner et al. 2005; O’Hagan et al. 2011).”
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis (2006, neutral): “30).”
Epigenetic gene silencing in cancer: the DNA hypermethylome. (2007, background): “Additional connections have been found: DNMTs are able also to recruit HDACs (41,42), while on the other hand, both DNMTs and MBDs recruit histone methyltransferases (HMTs) that modify lysine 9 of histone H3 (43,44).”
The interplay of histone modifications – writers that read (2015, positive): “A major site of the H3K9me3 modification is at pericentric heterochromatin, where there are self-reinforcing feedback loops involving the chromodomaincontaining protein HP1 which can bind to H3K9me3, and recruit de novo DNA methyltransferases (DNMT3A/B) [117,118].”
Ki-67: more than a proliferation marker (2018, background): “…of proteins involved in heterochromatin formation, including DNA methyltransferases DNMT1 and DNMT3a, histone methyltransferase SUV39H1, and the p150 subunit of the chromatin assembly factor-1 complex (CAF-1) (Murzina et al. 1999; Lachner et al. 2001; Fuks et al. 2003; Hiragami-Hamada et al. 2016).”
DNA Methylation and Its Basic Function (2013, background): “and repress gene transcription (Jones et al, 1998; Nan et al, 1998; Fuks et al, 2003).”
The role of RNA interference in heterochromatic silencing (2004, background): “In mammals, the DNA-methyltransferases Dnmt1 and Dnmt3b interact with the Suv39h (Suppressor of variegation 3-9 homologue) H3K9 methyltransferase and HP1, respectively, providing biochemical support for a functional link between DNA and histone methylatio”
HP1 and the dynamics of heterochromatin maintenance (2004, background): “In addition to self-association, HP1 interacting partners include the DNA methyltransferases Dnmt1 and Dnmt3a, which are involved in CpG methylatio”
Gardening the genome: DNA methylation in Arabidopsis thaliana (2005, background): “For example, mouse MBD-protein complexes can lead to further repressive chromatin modifications such as histone methylation and deacetylatio”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “HP1 binds directly to the PHD-like motif of DNMT3A in vitro.(28) The direct physical link identified between the DNMTs and the H3K9me-HP1 system therefore ensures that H3K9 methylation directly influences DNA methylation patterns.”