CD4 T cells: fates, functions, and faults.

By Jinfang Zhu, W. E. Paul. Blood, 2008

1,860 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bca48f09a0f3a7e9e14ef74264bc85782894efbd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Vitamin D: modulator of the immune system. (2010, background): “Furthermore, 1,25(OH)2D3 also modulates DC-derived cytokine and chemokine expression, by inhibiting the production of IL-12 and IL-23 (known as major cytokines driving Th1differentiation and Th17-differentiation respectively), and enhancing the release of IL-10 (a cytokine exerting broad-spectrum an”
How are TH2-type immune responses initiated and amplified? (2010, background): “Naive CD4 + T cells differentiate into at least four types of T helper (T H ) cell”
Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “Upon activation by T-cell receptor (TCR)- and cytokinemediated signaling, naive CD4 T cells may differentiate into at least four major types of T-helper (Th) cells, Th1, Th2, Th17, and inducible T-regulatory (iTreg) cells, that play a critical role in orchestrating adaptive immune responses to vario”
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “In this respect, CD4+ T cell subsets are thought to be distinct lineages, as defined by the cytokines they produce (Zhu and Paul, 2008).”
FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “in vitro and in vivo have provided important insights into the derivation of different effector Th cell lineages and is the basis for most studies on Th cell lineage development (Zhu and Paul, 2008).”
Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy (2016, neutral): “The effects of IL-13 on immune cells is similar to IL-4.”
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. (2008, background): “A growing body of evidence indicates that Th17 cells play a critical function not only in protection against microbial challenges but also in many organ-specific autoimmune diseases, including multiple sclerosis and its disease model experimental autoimmune encephalomyelitis (45).”