Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

By V. Brochard, B. Combadière, A. Prigent, Y. Laouar, A. Perrin, V. Beray-Berthat, O. Bonduelle, D. Alvarez-Fischer, J. Callebert, J. Launay and 4 more. Journal of Clinical Investigation, 2008

1,120 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/fdcb4e24dc77cd0bf6a346f06f989a157d83c267

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond (2009, background): “Moreover, MPTP-induced dopaminergic cell death was markedly attenuated in the absence of mature T lymphocytes (Brochard et al., 2009).”
Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “…DNR no Town et al., 2008 T cells + human no Rogers et al., 1988; Togo et al., 2002 APP/IFN-g Monsonego et al., 2006 CD4+ T cells – MPTP, human no Brochard et al, 2009; Kurkowska- Jastrzebska et al., 1999 CD8+ T cells role unknown MPTP, human no Brochard et al., 2009; Kurkowska- Jastrzebska et…”
Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “Additional factors that influence risk include polymorphisms in the T cell receptor b chain (TCR-b), CTLA4, TNF-a, ICAM1, CCR5, IL-10, IL-4R a chain, IL-2R b chain, IL-7R a chain, IFN-g, CD6, IRF8, TNFSF1A (TNFRI), vitamin D receptor, and the estrogen receptor (Fugger et al., 2009).”
Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction (2023, result): “Concerning the involvement of the adaptive immune system in PD neuropathology, data obtained from human studies and animal experiments have shown infiltrations of both CD8+ and CD4+ T cells in the SNpc of PD subjects [70, 71] (Fig.”
Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention (2009, background): “MPTP-intoxicated mice (Brochard et al., 2009) raise the interesting possibility that infiltration of peripheral T cells may have a”
Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity (2014, positive): “In this sense, in ALS, lymphocytic infiltrates and antibody deposits were detected in postmortem CNS tissues [57] and, more recently, increased CD4 and CD8 T cells were found to invade the brain in postmortem human specimens and in a mouse model of PD [58].”
Microglia: biology and pathology (2009, background): “Second, T cells are not usually observed in Parkinsonian substantia nigra and a report claiming the presence of small numbers of scattered cells [21] is awaiting independent confirmation.”
Neuroinflammation in Parkinson’s disease and its potential as therapeutic target (2015, background): “Conversely, mice deficient in T- and B-lymphocytes are more resistant to the neurotoxicity caused by MPTP intoxication [16, 96].”