Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study.

By J. Spranger, A. Kroke, M. Möhlig, K. Hoffmann, M. Bergmann, Michael Ristow, H. Boeing, A. Pfeiffer. Diabetes, 2003

1,589 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/ba63b23b15b455b70a37e36c39ae43e1456a8e06

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

In Epidemiology

In Physiology

Citations in the corpus

Adipocytokines in Obesity and Metabolic Disease (2014, positive): “Plasma aP2 levels are closely associated with obesity and metabolic syndrome in cohorts of multiple ethnicities (Stejskal & Karpisek 2006, Xu et al. 2006, Simon et al. 2009).”
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. (2013, background): “Proinflammatory cytokines, such as TNF-a and IL-1b, are significantly elevated in T2D (Herder et al., 2009; Spranger et al., 2003). u-3 FAs have been reported to enhance systemic insulin sensitivity via inhibition of TNF-a signaling pathway (Oh et al., 2010), however, some animal studies and several”
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age (2015, background): “Elevated proinflammatory cytokines and chemokines are closely associated with mortality (4, 5) and with a variety of age-related diseases, including atherosclerosis (6), depression (7), cancers (8), diabetes (9), and neurodegenerative diseases (10, 11).”
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. (2014, background): “[16] Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, et al.”
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB (2005, positive): “We isolated IKK complexes from mouse liver lysates using anti-IKK-γ antibodies (PharMingen) coupled to protein A-Sepharose, and conducted in vitro kinase assays at 30 °C by adding [γ-32P]ATP and 2 μg of GST-IκBα (1-54)12.”
Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “…CRP are risk factors for the development of illnesses associated with inflammation, such as heart disease and type 2 diabetes (Mendall et al., 1997, Spranger et al., 2003), and individuals with major depression have a several fold greater risk of comorbidity and mortality (Muskin, 2010, Shah et…”
Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). (2009, background): “In the ER, ARTS trims peptides to optimal length for presentation to MHC class I molecules, while at the cell surface it cleaves receptors for the proinflammatory cytokines IL-1, IL-6, and TNF (Figure 4).”