Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-101

By R. Lang, D. Patel, J. J. Morris, Robert L. Rutschman, P. Murray. Journal of Immunology, 2002

649 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/ba322ecb857e9b5bac9b8a45afe0422fc66c1ec2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Murray
4. Lisa M. Coussens
5. Carol A. Colton
6. D. Mosser
7. Xia Zhang
8. B. Ruffell

In Oncology

1. A. Mantovani
2. A. Sica
3. Lisa M. Coussens
4. B. Ruffell
5. D. Mosser
6. P. Murray
7. Nesrine I. Affara
8. P. Allavena

Citations in the corpus

• Microglial M1/M2 polarization and metabolic states (2016, background): “Upon STAT6 activation, induction occurred in Ym1, Mrc1 and Fizz1.”
• Macrophage phenotypes in atherosclerosis (2014, background): “Likewise, IL-10 upregulates the expression of M2 phenotype genes through the activation of the STAT-3 pathway in mice (85, 86).”
• The regulation of IL-10 production by immune cells (2010, background): “By contrast, IL-10 positively feeds back to upregulate Tpl2 expressio”
• STAT3 signaling in immunity (2016, background): “effects of IL-10 was firmly established by several groups [165–168], yet the cell intrinsic mechanism whereby STAT3 restrains proinflammatory gene expression has been elusive for nearly a decade.”
• Functional plasticity of macrophages: reversible adaptation to changing microenvironments (2004, background): “[16] revealed that lipopolysaccharide (LPS) induced 259 of the screened genes and that IL-10 repressed 62 of these and enhanced 15 others [16].”
• Macrophage activation and polarization: nomenclature and experimental guidelines (2014, neutral): “…alone, LPS, LPS ed and unpublished data from the authors’ laboratories and represent a starting ndra et al., 2014; Krausgruber et al., 2011; Lang et al., 2002; Shirey et al., 2008; boration of human IL-4 genes by deep sequencing (K.A.S. and S.N.V., data not d Klf4 cause a ‘‘switch’’ to…”
• Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences1 (2005, background): “Gene array studies indicate that an activating signal such as LPS can induce expression of hundreds of genes in macrophages and that the expression of these genes is differentially regulated by different cytokines (9, 10, 20).”
• Macrophage plasticity and polarization: in vivo veritas. (2012, positive): “IL-10 activates STAT3-mediated expression of genes (Il10, Tgfb1, Mrc1) associated with an M2-like phenotype (4, 15, 16).”
• Biochemical and functional characterization of three activated macrophage populations (2006, background): “Resident tissue macrophages (M ) can rapidly respond to external stimuli with dramatic alterations in gene expression [1].”
• Differential Macrophage Programming in the Tumor Microenvironment (2012, positive): “IL-10 also synergizes with IL-4 to induce Arginase-1 expression in macrophages, possibly through induction of IL-4Rα [103].”