Differential Macrophage Programming in the Tumor Microenvironment
By B. Ruffell, Nesrine I. Affara, Lisa M. Coussens. Trends in immunology, 2012
839 citations recorded by the source corpus.
Of the multiple unique stromal cell types common to solid tumors, tumor-associated macrophages (TAMs) have been recognized as significant for fostering tumor progression. The protumor properties of TAMs are derived from their ability to regulate angiogenic programming, provide soluble mediators to malignant cells for proliferation, survival and invasion, and for directly and indirectly suppressing activity of cytotoxic T cells. These varied activities are dependent on the polarization state of TAMs that is regulated in part by local concentrations of cytokines and chemokines, as well as varied interactions of TAMs with normal and degraded components of the extracellular matrix. Targeting molecular pathways regulating TAM polarization holds great promise for anti-cancer therapy.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/81b1ca18d537fea734439dfacdb4f66cb1f41889
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Citations in the corpus
- Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor immune microenvironment (2013, background): “TAMs inhibit T cell responsiveness via expression of arginase-1 (Ruffell et al., 2012).”
- Antibody distance from the cell membrane regulates antibody effector mechanisms (2017, background): “It is now evident that the tumor microenvironment can promote infiltrating immune cells to adopt a more protumor/immune-suppressive phenotype (61); however, its direct effect on mAb therapy once again is unclear.”
- Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells (2014, background): “That said, the increased diversity of leukocytic infiltrates in human breast cancer (Ruffell et al., 2012b), and our observation that breast tumor epithelial cells expressed IL-10, argues that neutralizing the effects of IL-10 in human breast cancer may require more selective targeting to maximize…”
- Oncolytic viruses: a new class of immunotherapy drugs (2015, background): “For example, tumour cells and the microenvironment can express immuneinhibitory surface receptors that inactivate effector immune cells, and secrete factors -such as IL-10, transforming growth factor-β (TGFβ) and indoleamine-2,3dioxygenase (IDO) -that facilitate the recruitment of immune-suppressive”
- The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases (2016, background): “The involvement of M1/M2 in obesity, atherosclerosis, and cancer is briefly discussed below; the comprehensive reviews on human diseases have been published elsewhere [28–30].”
- Macrophage Polarization in Inflammatory Diseases (2014, background): “For example, TAM in hypoxic zones of solid tumors may express Arg1, a marker of M2 phenotype, but this phenomenon is not found in areas near functional vasculature [77].”
- Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, neutral): “Clinically, the presence of macrophages within primary tumors have been shown to be correlated with poorer prognosis in almost all tumors [7][42], with the exception of colon cancers [43].”
- M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide (2015, background): “Many studies have shown on one hand an inverse correlation between macrophage abundance in a tumor and patient prognosis and survival, and on the other hand a positive correlation with resistance to chemotherapy [11, 27–29].”