Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences1

By R. Stout, Chuancang Jiang, B. Matta, Illya Tietzel, S. Watkins, J. Suttles. Journal of Immunology, 2005

1,030 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/364e56a5bc9e3ba4a50a2e9786c1293e43ca4628

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In Immunology

1. A. Mantovani
2. A. Sica
3. S. Gordon
4. P. Murray
5. TA Wynn
6. F. Martínez
7. R. Medzhitov
8. Subhra K. Biswas

In Neurology

1. A. Mantovani
2. TA Wynn
3. T. Koh
4. Subhra K. Biswas
5. S. Gordon
6. P. Murray
7. A. Sica
8. F. Martínez

Citations in the corpus

• Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds (2014, positive): “In contrast, macrophages change their behavior in response to subtle changes in their microenvironment, including the sequential administration of synergistic and/or antagonistic stimuli [51].”
• Biochemical and functional characterization of three activated macrophage populations (2006, result): “Thus, the nature, order, and/or duration of stimulation can influence cytokine production, as reported previously [26].”
• Obesity induces a phenotypic switch in adipose tissue macrophage polarization. (2007, background): “one polarization state to another depending upon environmental stimuli (48).”
• The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages (2010, background): “However features of polarization are likely to represent a continuum within a population of cultured cells and to be highly adaptable to prevailing stimuli [39].”
• Tissue-specific signals control reversible program of localization and functional polarization of macrophages. (2014, positive): “In addition, mature macrophages can undergo functional polarization in response to environmental signals (Stout et al., 2005).”
• Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “Since most immunomodulatory therapies are directed against microglia already activated by insult or injury, it is extremely important to determine if the response to pharmacological treatments is affected by previously acquired microglial phenotypes (Stout et al., 2005).”
• INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, neutral): “Related to these findings perhaps, is the broader issue of plasticity within macrophage populations, which in vitro can switch expression levels of hallmark CAM or AAM markers after initial polarization, resulting in mixed marker patterns (84, 85); whether dectin-1-mediated recognition among AAMs is”
• Microglial M1/M2 polarization and metabolic states (2016, background): “Within injured tissue, microglia exist in various states of activation and retain the capability to shift their functional phenotype during the inflammatory response (Stout et al., 2005; Graeber, 2010).”
• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, result): “Other studies demonstrated that M2 macrophages are reprogramed to express M1 genes following exposure to TLR ligands or IFN-γ (192, 193).”
• Macrophage phenotypes during tissue repair (2013, background): “Additionally, Mp remain responsive to further stimuli after their initial activation [19, 27].”
• Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance (2014, background): “For example, M2 macrophages can be re-polarized into macrophages with M1 phenotype following exposure to TLR ligands or IFNγ or overexpression of miR-155 (113, 114), whereas M1 macrophages can be reprogramed to express various genes of M2 macrophage by treating macrophages with reagents that increas”
• Biomaterial based modulation of macrophage polarization: A review and suggested design principles (2015, background): “This is emphasized by the contrasting gene expression during early and late stages of the FBR [24], as well as their ability to adapt functionality in response to the temporal presentation of stimuli [25].”
• Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord (2009, background): “Indeed, macrophage phenotype and function are dynamically regulated by the tissue microenvironment with recent data showing that macrophages can change their phenotype in response to sequential stimuli (Stout et al., 2005).”