The regulation of IL-10 production by immune cells

By M. Saraiva, A. O’Garra. Nature reviews. Immunology, 2010

3,203 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1a88f17d60f3707bdb3e09f14af712cd0edf6192

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In Immunology

Citations in the corpus

Regulation of intestinal epithelial permeability by tight junctions (2012, background): “Interleukin-10 (IL-10), a homodimeric cytokine mainly produced by Th2 cells, regulatory T cells, monocytes/ macrophages, and dendritic cells, is regarded as an antiinflammatory cytokine [130, 131].”
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation (2011, positive): “Among these mediators, IL-10, which can be produced by multiple immune cell types, plays a particularly prominent role in curtailing immunemediated inflammation in the context of infection, allergy, and autoimmunity (Moore et al., 2001; Saraiva and O’Garra, 2010).”
The Role of the Transcription Factor CREB in Immune Function (2010, background): “IL-6) and the anti-inflammatory cytokine IL-10 (29).”
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “5 (Saraiva and O'Garra, 2010), CD4 T cells appear to be a key functional source (Roers et”
Intestinal homeostasis and its breakdown in inflammatory bowel disease (2011, background): “Unlike FOXP3-expressing cells, FOXP3 − IL-10 + CD4 + cells may represent a more heterogeneous mix, because most effector T H -cell subsets, including T H 1, T H 2 and T H 17 cells, produce IL-10 after chronic immune stimulatio”
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses (2011, background): “Il10 −/− mice develop spontaneous autoimmune diseases and show greater resistance to infectio”
Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells (2014, background): “In sharp contrast to these studies, response to CTX in subcutaneous tumor models has been found to occur independently of IL-12 and Batf3dependent DCs and is instead mediated by an immune cell/ cytokine pathway involving IFN-b, IL-17, and IFN-g, with production by CD11b+CD103+ DCs, gd T cells, and C”
The immune response in tuberculosis. (2013, background): “IL-10 is an immunosuppressive cytokine essential for dampening the immune response and limiting host immune pathology to numerous intracellular pathogens and gut flora, but, if overproduced, IL-10 can contribute to chronic infection (290).”