Cell movement is guided by the rigidity of the substrate.

By C. Lo, Hong Wang, Micah Dembo, Yu-li Wang. Biophysical Journal, 2000

3,227 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology

View Paper: https://www.semanticscholar.org/paper/b9cf8ff15bdf02c7e1660e36be91eb03a1d3773f

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In Biomedical Engineering

In Cell Biology

Citations in the corpus

Random versus directionally persistent cell migration (2009, background): “and durotaxis in response to mechanical signals in the environmen”
Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion (2005, background): “E-mail: aputnam@uci.edu Received 10 July 2004; Accepted 4 November 2004 DOI: 10.1002/jcp.20274 1997; Pelham and Wang, 1997, 1998; Lo et al., 2000; Wang et al., 2001; Beningo and Wang, 2002; Engler et al., 2004).”
Physics of adherent cells (2013, background): “For example, cells tend to migrate from softer to more rigid substrates and to have larger adhesive regions and overall spread area on more rigid substrates (Pelham and Wang, 1997; Lo et al., 2000; Engler, Bacakova et al., 2004; Trichet et al., 2012).”
Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “The migration rate of many cell types is optimized at intermediate levels of adhesion, and modulating the density or mechanical compliance of the ECM alters migration speed in a biphasic fashion (Gaudet et al. 2003, Lo et al. 2000, Palecek et al. 1997, Pelham & Wang 1997, Peyton & Putnam 2005).”
Balancing forces: architectural control of mechanotransduction (2011, neutral): “This probably requires fast dynamic coordination between the mechano-sensors (integrins) and response elements (actin cytoskeleton) that direct motilit”
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. (2005, background): “soft but equally adhesive surfaces and that cells will preferentially migrate from a soft to a hard surface [Lo et al., 2000].”
Blebs lead the way: how to migrate without lamellipodia (2008, background): “, allowing cells to selectively migrate towards stiffer regions of the substrate (durotaxis”
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin signaling (2009, background): “ECM stiffness enhances cell growth and survival and promotes migration (Lo et al., 2000), and ECM rigidity disrupts tissue morphogenesis by increasing cell tension (Paszek et al.”
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression (2010, background): “Because cells have previously been shown to preferentially migrate toward stiffer regions when cultured on substrates with sharp stiffness gradients (Lo et al., 2000), we measured lung fibroblast migration at various locations along the stiffness gradient.”
The biomechanics toolbox: experimental approaches for living cells and biomolecules (2003, background): “[36] have created a polyacrylamide gel for which the polyacrylamide concentration and thus the elastic compliance change at a well-defined interface, and seeded fish fibroblasts onto one side of this ECM-coated substrate.”
Three-dimensional Full-field Measurements of Large Deformations in Soft Materials Using Confocal Microscopy and Digital Volume Correlation (2007, background): “The importance of mechanical signals in directing cellular behaviors such as adhesion, motility, differentiation and morphogenesis has become evident in recent years [1–4].”