Random versus directionally persistent cell migration

By R. Petrie, A. Doyle, Kenneth M. Yamada. Nature reviews. Molecular cell biology, 2009

998 citations recorded by the source corpus.

Directional migration is an important component of cell motility. Although the basic mechanisms of random cell movement are well characterized, no single model explains the complex regulation of directional migration. Multiple factors operate at each step of cell migration to stabilize lamellipodia and maintain directional migration. Factors such as the topography of the extracellular matrix, the cellular polarity machinery, receptor signalling, integrin trafficking, integrin co-receptors and actomyosin contraction converge on regulation of the Rho family of GTPases and the control of lamellipodial protrusions to promote directional migration.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6095f801faa2ad560152a9bbb1438a0bcfc79929

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In Cell Biology

1. Ali Khademhosseini
2. J. Condeelis
3. Clare M. Waterman
4. Pengfei Lu

In Immunology and Allergy

1. J. Condeelis
2. Clare M. Waterman

In Molecular Biology

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Citations in the corpus

• Chemotaxis in cancer (2011, background): “Different types of directed cell migration have been observed in tumour cells: chemotaxis, haptotaxis , electrotaxis and durotaxis”
• Engineering microscale topographies to control the cell–substrate interface (2012, background): “Persistently directional migration requires a motogen—a signal that activates a cell’s internal motility machinery—along with an asymmetric external cue that guides the direction of movement [21].”
• Nanotopography-guided tissue engineering and regenerative medicine (2012, background): “[4], electric fields (electrotaxis) [5], and chemical factors (chemotaxis) [6,7].”
• The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function (2011, neutral): “How might podosomes and invadopodia control cell motility? Planar cell migration is facilitated by the coordination of focal adhesion assembly, maturation and turnover with the protrusion of the leading edge at lamellipodi”
• Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration (2012, background): “Such cues may be diffusible or substrate-bound biochemicals, as in chemotaxis and haptotaxis, or physical, including electric fields, topography, or extracellular matrix (ECM) rigidity (Petrie et al., 2009).”
• Quantitative and unbiased analysis of directional persistence in cell migration (2014, background): “In many instances, cell migration is biased by external cues, such as chemoattractants, extracellular matrices or electrical fields 9 .”