Blebs lead the way: how to migrate without lamellipodia
By G. Charras, E. Paluch. Nature reviews. Molecular cell biology, 2008
771 citations recorded by the source corpus.
Blebs are spherical membrane protrusions that are produced by contractions of the actomyosin cortex. Blebs are often considered to be a hallmark of apoptosis; however, blebs are also frequently observed during cytokinesis and during migration in three-dimensional cultures and in vivo. For tumour cells and a number of embryonic cells, blebbing migration seems to be a common alternative to the more extensively studied lamellipodium-based motility. We argue that blebs should be promoted to a more prominent place in the world of cellular protrusions.
Subfields: Biomedical Engineering, Cell Biology
View Paper: https://www.semanticscholar.org/paper/bdce60d0918d24e24e8eb6f66a44052dfe13ef48
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In Biomedical Engineering
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Citations in the corpus
- The Actin Cytoskeleton and Actin-Based Motility (2018, background): “In this case, blebs are thought to advance the cell front instead of lamellipodia and filopodia (Charras and Paluch 2008).”
- Rho GTPase signalling in cell migration (2015, background): “Bleb-driven cell migration Bleb-based migration is driven by cortical actomyosin contractility (Figure 3), and is associated with high levels of active RhoA/ROCK signalling [79].”
- Life at the leading edge. (2011, background): “Membrane blebbing has been described to drive directional cell migration during development (Charras and Paluch, 2008), and invadopodia are protrusions that allow focal degradation of the extracellular matrix, probably to facilitate invasion through the tissues (Buccione et al.”
- Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “Called amoeboid motility, this is a mode of locomotion well-studied in the amoeba Dictyostelium (55, 89, 349).”
- In vitro cell migration and invasion assays. (2013, background): “This is called blebby amoeboid migration [13,16,17] and is used for example by embryonic cells, leukocytes migrating through the ECM (3D migration) or by certain cancer cells.”