Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.

By T. Yeung, Penelope C. Georges, L. Flanagan, B. Marg, Miguelina Ortiz, M. Funaki, Nastaran Zahir, W. Ming, Valerie M. Weaver, P. Janmey. Cell Motility and the Cytoskeleton, 2005

2,418 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/08a59ff1e3da1f942c4d9559a12a29ab29873aad

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Citations in the corpus

The myofibroblast: paradigm for a mechanically active cell. (2010, background): “Under these conditions the significance of the substrate may be low compared with the mechanical influence of the neighboring cells (Yeung et al., 2005).”
Physics of adherent cells (2013, background): “In addition, the forces that even static cells exert on substrates have been shown to increase with substrate rigidity (Choquet, Felsenfeld, and Sheetz, 1997; Saez et al., 2005; Yeung et al., 2005; Zemel et al., 2010a).”
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells (2009, background): “Examples include growing cells on microarrays of posts to quantify the traction forces exerted [12] and on substrates of varying mechanical stiffness to compare cell behavior [15,16].”
Matrix density-induced mechanoregulation of breast cell phenotype, signaling, and gene expression through a FAK-ERK linkage (2009, positive): “Polyacrylamide substrates were prepared as described by Pelham and Wang (Pelham & Wang, 1997) and Yeung et al., (Yeung et al., 2005).”
Tensional homeostasis and the malignant phenotype. (2005, background): “Furthermore, integrin expression is higher in epithelia on rigid two-dimensional (2D) substrata than on a compliant 3D matrix (Delcommenne and Streuli, 1995), and matrix rigidity increases integrin expression (Yeung et al., 2005).”
Fibroblast adaptation and stiffness matching to soft elastic substrates. (2007, methodology): “tetramethylethylenediamine, as described previously (6), following a method”
The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, positive): “This is important as the physical properties of the environment, such as ECM stiffnes”