Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
By Fei Liu, Justin D. Mih, B. Shea, A. Kho, Asma S. Sharif, A. Tager, D. Tschumperlin. Journal of Cell Biology, 2010
769 citations recorded by the source corpus.
In response to tissue stiffening, fibroblasts increase production of extracellular matrix while decreasing production of matrix-degrading enzymes and the fibrosis inhibitor prostaglandin E2.
Subfields: Sociology and Political Science
View Paper: https://www.semanticscholar.org/paper/c9345367ca1366bee6f7394e2c4e04545e061360
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Citations in the corpus
- Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. (2012, background): “1 toz 3 kPa), whereas higher stiffness levels (20–50 kPa) induced an appearance of activation characterized by accumulation of cells aligned in parallel clusters (49).”
- The myofibroblast matrix: implications for tissue repair and fibrosis (2013, neutral): “myofibroblast activation in the setting of fibrosis [186].”
- Dynamic molecular processes mediate cellular mechanotransduction (2011, neutral): “Fibrotic lung disease begins with a small change in tissue stiffness, which is sensed by cells, inducing more severe, irreversible remodellin”
- TGF-β1 Signaling and Tissue Fibrosis. (2018, background): “…also profoundly affects the behavior of tissue fibroblasts, with increased stiffness favoring increased collagen production and expression of contractile proteins such as asmooth muscle actin (SMA), and decreased stiffness favoring a more quiescent and noncontractile phenotype (Liu et al. 2010).”