A niche for adult neural stem cells.

By F. Doetsch. Current Opinion in Genetics and Development, 2003

678 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b71e70552efdb3570b530bc239ec1a4155ed97fa

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Citations in the corpus

BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Within these areas, the interactions between stem cells and their neighboring cells determine many vital properties of stem cells, including self-renewal, proliferation, and cell fate determination (55, 117).”
FoxO3 regulates neural stem cell homeostasis (2009, positive): “FoxO factors have recently been found to regulate the self-renewal of adult hematopoietic stem cells (HSCs), primarily by providing resistance to oxidative stress (Miyamoto et al., 2007; Tothova et al., 2007).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “Within adult neurogenic niches, astrocytes are stem cells in the adult SVZ in both rodents (reviewed in Doetsch 2003a) and humans (Sanai et al. 2004), yet there may be fundamental differences in how neural stem cells from the two species interpret these molecular signals and ultimately affect their…”
Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “Adult neurogenesis is tightly regulated by their local environment, or ‘neurogenic niche’ (Doetsch, 2003; Alvarez-Buylla & Lim, 2004).”
The therapeutic potential of neural stem cells (2006, background): “The ganglionic eminence(s) in the embryo, and both the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) in the adult have consistently been shown to contain stem-cell-like precursors capable of driving neurogenesis and gliogenes”
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. (2014, background): “Similar to the SVZRMS, polySia-positive neuroblasts are generated from astrocytic stem cells in this second major neurogenic niche of the adult brain (121, 229).”
Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions (2008, positive): “Previous studies have identified the major neural cell types and their lineal relationships in the adult SVZ: type B stem cells give rise to type C transit-amplifying cells, which, in turn, produce the type A neuroblasts (Doetsch, 2003).”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “This is also seen in some mammalian tissues, for example in the central nervous system where neural stem cells reside throughout postnatal life in the lateral ventricle subventricular zone (Doetsch, 2003) and dentate gyrus of the hippocampus (Palmer et al.”
The mystery and magic of glia: a perspective on their roles in health and disease. (2008, background): “In oligodendrocytes, secretory lysosomes secrete myelin proteins and likely play a critical role in myelination (Trajkovic et al., 2006).”
The glial identity of neural stem cells (2003, background): “Ependymal cells, however, participate in creating a specialized neurogenic niche in the SVZ by producing noggin, an antagonist of bone morphogenetic proteins, which promote astroglial differentiation in this regio”
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell (2005, background): “In vivo, stem cells are thought to reside in specific cellular microenvironments, or niches, that constitute privileged settings for support of selfrenewal [1–4].”
Stem cell niche: structure and function. (2005, background): “…y. ANRV255-CB21-25 ARI 8 September 2005 17:11 subgranular zone (SGZ) of the hippocampus region are the primary and well-characterized germinal regions in which NSCs reside and support neurogenesis in the adult brain (Doetsch 1999, 2003, Lois & Alvarez-Buylla 1993, Palmer et al. 1997, Temple 2001).”