The glial identity of neural stem cells

By F. Doetsch. Nature Neuroscience, 2003

762 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/48b8ae4a78b51cc0e3171e32a579c45d2405092e

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Citations in the corpus

Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell (2005, background): “However, recent fate mapping analysis [69] indicates that a subset of radial glia give rise to the sub-ventricular zone astrocytes that function as adult neural stem cells [70,71].”
The origin and development of glial cells in peripheral nerves (2005, background): “In principle, these observations on SCPs parallel the recent observation that radial glia give rise to CNS neurons during developmen”
The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting (2016, background): “…to be at least ten glia per neuron”) Haydon, 2001 10:1 (“or more”) Levitan & Kaczmarek, 2002 100 bn Haines, 2002 (“glia are the most numerous cells in the brain”) Doetsch, 2003 10:1-50:1 [1.1-5.1 trn] [1-5 trn] 100 bn Hatton & Parpura, 2004 10:1 Bear et al., 2007, 3rd ed 10:1 > “several…”
Seasonal hippocampal plasticity in food-storing birds (2010, methodology): “The role of radial glia as neural stem cells in the avian brain is somewhat surprising but parallels the neural stem cell role of glia in the mammalian subventricular and subgranular zones (Doetsch 2003).”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Type C cells, in turn, give rise to immature neuroblasts (type A cells), which migrate along the RMS to the olfactory bulb, where they terminally differentiate into various types olfactory bulb interneurons (56, 132).”
Experience dictates stem cell fate in the adult hippocampus. (2011, positive): “Remarkably, NSCs in the more active upper blade of the dentate gyrus produced many neurons, consistent with the presence of an intermediate transit amplifying cell (Clayton et al., 2007; Doetsch, 2003; Jones et al., 2007; Nakagawa et al., 2007; Zhao et al., 2008).”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “The hippocampal stem cell lineages and microenvironment that support neurogenesis have been extensively reviewed elsewhere (for examples, see Ref”
Late-Stage Neuronal Progenitors in the Retina Are Radial Müller Glia That Function as Retinal Stem Cells (2007, background): “Radial glia also give rise to adult neural stem cells in the mammalian telencephalon (Doetsch, 2003; Merkle et al., 2004).”
Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression (2005, background): “Because the GCL contains high concentrations of GR and mineralocorticoid receptor (MR), corticosteroid signaling has therefore been proposed to occur indirectly via, e.g., neighboring mature granule cells, through astrocytes or radial glial cells (Doetsch, 2003).”
A Specialized Vascular Niche for Adult Neural Stem Cells (2008, background): “In both regions, astrocytes, glial cells that have long been considered support cells in the brain, are neural stem cells (Doetsch, 2003).”
Mechanisms of asymmetric stem cell division. (2008, background): “Given that adult neural stem cells have glia identity as well (Doetsch, 2003) it is quite likely that the principles found during development are applicable to adult neurogenesis as well.”
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh (2009, background): “During brain development, periventricular NSCs have radial glia morphology and express RC2 and BLB”
The Human Brain in Numbers: A Linearly Scaled-up Primate Brain (2009, neutral): “Many original articles, reviews and textbooks affi rm that we have 100 billion neurons and 10 times more glial cells (Kandel et al., 2000; Ullian et al., 2001; Doetsch, 2003; Nishiyama et al., 2005; Noctor et al., 2007; Allen and Barres, 2009), usually with no references cited.”