Microglia in neurodegenerative disease

By V. Perry, J. Nicoll, C. Holmes. Nature Reviews Neurology, 2010

1,554 citations recorded by the source corpus.

Subfields: Immunology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/b6942da969e0d79240c5d089a56def12f380a2cb

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Citations in the corpus

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration (2011, result): “These provocative preliminary results were recently succeeded by evaluation of individuals with Alzheimer's disease, with the finding that transient common infections such as upper respiratory infections or urinary tract infections can produce permanent worsening of ongoing neurodegenerative diseas”
Origin and differentiation of microglia (2013, background): “Adequate and appropriate microglial function is crucial for the homeostasis of the CNS in both health and disease (Perry et al., 2010).”
The myeloid cells of the central nervous system parenchyma (2010, background): “The concept that activation of microglia occurs along a linear range, as suggested by the descriptive morphology of the cells in a variety of diseases and models, has been discarde”
Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission (2011, background): “Microglia is the other major glial cell type of the brain, and its role has mostly been characterized in pathologies (8, 9).”
Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro (2013, background): “Inflammatory processes, including activation of microglia, are initiated in the adult and perinatal brain after most (if not all) types of insults and injury (see, Degos et al., 2010; Perry et al., 2010; Bilbo et al., 2012; Fleiss and Gressens, 2012; Hagberg et al., 2012).”
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “Interestingly, changes in morphology may correspond to alterations in microglial function (Perry et al., 2010), and these microglial functional changes are related to the brain damage or repair.”
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease (2013, background): “Extrapolating from this data-driven interaction, it is possible that TYROBPmay be associated with neuronal pruning activity of the complement system that may be reawakened in LOAD via amyloid-b and tau aggregates (Perry et al., 2010).”
Microglial cell origin and phenotypes in health and disease (2011, background): “However, prolonged or excessive microglial cell activation may result in pathological forms of inflammation that contribute to the progression of neurodegenerative and neoplastic disease”
Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “Neuroinflammation is a prominent feature of many neurodegenerative diseases (Eikelenboom et al., 2010; Perry et al., 2010), and is increasingly being recognized as an important pathophysiological mechanism underlying chronic neurodegeneration following traumatic brain injury Experimental Neurology…”