Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

By O. Pascual, Sarrah Ben Achour, P. Rostaing, A. Triller, A. Bessis. Proceedings of the National Academy of Sciences of the United States of America, 2011

673 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/6c3992e5fed64a3e117130d411e5d243d4870284

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Microglia: Dynamic Mediators of Synapse Development and Plasticity (2015, methodology): “LPS (500 ng/ml) (TLR4-mediated ATP release and activation of P2Y1) Triggers LTP by activation of mGluR5 in mouse hippocampal slices [38]”
Microglia: new roles for the synaptic stripper. (2013, positive): “Under physiological conditions, the low levels of TNF-a (acting at about 100 picomolar concentrations) is a potent effector of synaptic scaling (Pascual et al., 2012; Stellwagen and Malenka, 2006), a uniform adjustment in the strength of all synapses formed on a given neuron in response to prolonged”
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner (2012, positive): “Furthermore, microglia can contribute to synaptic plasticity in the adult CNS and, more recently, in the context of the normal developing hippocampus (Paolicelli et al., 2011; Pascual et al., 2011; Roumier et al., 2008).”
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “110 Microglia have the potential to enhance the in ﬂ ammatory activation of astrocytes by increasing the expression level of cytokines and chemokines, speci ﬁ cally through the activation of nuclear factor-κ B (NF-κ B) signaling.”
Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “Organotypic slice cultures allow the in vitro study of microglial cell activation and function in a context that preserves the physiological environment and the neuron–glia interactions (Ajmone-Cat et al., 2013; Czapiga and Colton, 1999; Pascual et al., 2012).”
Astrocytes: Orchestrating synaptic plasticity? (2015, neutral): “(Bienenstock! et! al.,! 1982),! this! competition! is! introduced! thanks! to! a! metaplasticity! mechanism,! whereby! the! threshold!”
Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017, background): “Microglia-derived cytokines regulate synaptic scaling indirectly through astrocytes (82).”
The biphasic function of microglia in ischemic stroke (2017, positive): “Further experiments found that inhibition of mGluR5 receptor on neurons decreased the effect of LPS stimulation on neuronal activity, implicating that activated microglia induced astrocyte modulated neuronal activity through mGluR5 (Pascual et al., 2012).”