Microglial cell origin and phenotypes in health and disease

By Kaoru Saijo, Christopher K. Glass. Nature reviews. Immunology, 2011

1,059 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e2a4faae291c15a483fcd46ae7bfe36885c4bf0e

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Citations in the corpus

Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “Activated macrophages subtypes Molecules and molecular pathways involved in the acquisition of the classical pro-inflammatory M1 macrophage phenotype are reviewed elsewhere (Rivest, 2009; Saijo and Glass, 2011).”
The biphasic function of microglia in ischemic stroke (2017, neutral): “Inflammatory phenotype, also known as M1 phenotype, is characterized by the production of a variety of pro-inflammatory cytokines (IL-1b, IL-6, TNF-a, CCL2, and CXCL10), ROS, NO, and proteolytic enzymes matrix metalloproteinase-9 and matrix metalloproteinase-3 (Kettenmann et al., 2011; MacMicking et”
Macrophage plasticity, polarization, and function in health and disease (2018, positive): “…observed that embryonic and adultderived macrophages co-exist in many different organs (Davies et al., 2013; Divangahi et al., 2015; Galli, Borregaard, & Wynn, 2011; Guilliams et al., 2014; Saijo & Glass, 2011; Sheng, Ruedl, & Karjalainen, 2015; Stefater et al., 2011; Varol, Mildner, & Jung, 2015).”
Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia (2013, neutral): “Related to this, the investigation of microglia has been complicated by controversy and nomenclature disputes 1–3 and a challenge to investigators has been the development of markers that distinguish microglia from hematogenous infiltrating macrophages which have identical morphologies 2 .”
The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “Several mechanisms by which these cells maintain a quiescent state have been proposed, including interaction of microglial CX3CR1 receptor with its neuronal ligand the chemokine CX3CL1 and inhibitory signalling through the microglial cell surface proteins CD172, CD200R and CD45 with their neuronal l”
Microglia regulate the number of neural precursor cells in the developing cerebral cortex (2013, background): “, 2011) and a wealth of knowledge on microglial function in the mature brain (Kreutzberg, 1996; Kettenmann et al., 2011; Saijo and Glass, 2011), the functional roles of microglia during prenatal cortical development are not well understood.”
Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro (2013, background): “, 2009), suggested to relate to differing origin of these cell types (Saijo and Glass, 2011).”