Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
By V. Chhor, Tifenn le Charpentier, S. Lebon, Marie-Virgine Oré, Idoia Lara Celador, J. Josserand, V. Degos, E. Jacotot, H. Hagberg, K. Sävman and 3 more. Brain, behavior, and immunity, 2013
613 citations recorded by the source corpus.
Highlight ► A unique catalogue of phenotype markers and neuronotoxic effects of polarised primary microglia, as a comparative tool to screen neurotherapies.
Subfields: Immunology, Neurology
View Paper: https://www.semanticscholar.org/paper/3bf22d86addc8c0cbd02276346b15e198800d4e3
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Citations in the corpus
- Microglial M1/M2 polarization and metabolic states (2016, background): “M2 polarization of microglia is similar to peripheral macrophages (Fenn et al., 2012; Liu et al., 2012; Chhor et al., 2013; Freilich et al., 2013), generating different mRNA profiles for IL-4 and IL-10 stimulation including Arg1, Mmr, Ym1, found in inflammatory zone 1 (Fizz1) and Ppar (Michelucci et”
- Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “In agreement with these early studies, it has been shown that systemic LPS administration leads to the activation of microglial cells and the up-regulation of pro-inflammatory molecules as TNFa, COX2, iNOS, IL-1b, MHC-II, TLR2, IL-6 and IL-10 (Carrillo-de Sauvage et al., 2013; Cardona et al., 2006a,”
- The biphasic function of microglia in ischemic stroke (2017, neutral): “M2b phenotype could be induced by immune complexes and TLRs agonists, and IL-1R ligands and shows increased expression of IL1RA, CD86, and SOCS3 (Chhor et al., 2013; Mecha et al., 2015).”