The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

By Rick B. Vega, J. Huss, D. Kelly. Molecular and Cellular Biology, 2000

1,262 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/2c3bc408215939ae6a01af8fecb7da4d08bb0017

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Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. (2000, background): “PGC-1 gene expression was also evaluated in response to short-term fasting, a physiologic condition known to rapidly increase cardiac mitochondrial fatty acid utilization rates (34) and FAO enzyme gene expression by PPARα-mediated transcriptional activation (23).”
Metabolic control through the PGC-1 family of transcription coactivators. (2005, background): “…and β coactivate, one subset draws special attention; this includes NRF-1 and NRF-2 (Wu et al., 1999) and the nuclear hormone receptors, such as PPARα (Vega et al., 2000), PPARδ (Wang et al., 2003), ERRα (Huss et al., 2002; Huss et al., 2004; Kamei et al., 2003; Mootha et al., 2004; Schreiber et…”
PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “Finally, PGC-1α may also prevent ROS production and the apoptosis of endothelial cells by increasing FAO and enhancing the ATP/ADP activity of the adenine nucleotide translocator [215].”
Hepatocyte-specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation (2009, background): “Previous studies have demonstrated that PGC-1a, an inducible coactivator for a number of nuclear receptors and additional transcriptional factors, physically interacts with PPARa, thus stimulating its transcriptional activity (Vega et al., 2000).”
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1 (2002, background): “The effect of PGC-1 on mitochondrial biogenesis is probably explained at least in part by the finding that in addition to being a coactivator of PPAR, PGC-1 coactivates NRF-1 (26) and PPAR ( 28 ).”
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. (2004, background): “PGC-1 was cloned in a yeast two-hybrid screen for brown adipose-specific factors that interacted with the adipogenic nuclear receptor PPAR (Puigserver et al. 1998).”
Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle (2003, background): “More recently, PGC-1a has also been shown to enhance the activation of genes encoding for mitochondrial enzymes of the fatty acid b-oxidation pathway via coactivation of the PPARa transcription factor (Vega et al. 2000).”
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008, background): “In addition, activation of PGC-1a signaling most likely synergizes with increased PPAR expression, as PGC-1a is a coactivator of PPARa- and PPARb/d-mediated FAO (Vega et al., 2000; Wang et al., 2003).”