Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

By Luca Valenti, Ahmad E. Al-Serri, A. Daly, E. Galmozzi, R. Rametta, P. Dongiovanni, V. Nobili, E. Mozzi, G. Roviaro, E. Vanni and 5 more. Hepatology, 2010

623 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/1341b399a0f7c091e5cf5d3ec99fc662c2d68aea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Q. Anstee
2. C. Day
3. Z. Younossi
4. G. Targher

In Epidemiology

1. Q. Anstee
2. C. Day
3. Z. Younossi
4. G. Targher

Citations in the corpus

• Meta‐analysis of the influence of I148M variant of patatin‐like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease (2011, methodology): “Information about liver biopsy was available in six studies,(2-6,17) and data about disease severity was analyzed in 2,651 patients with NAFLD; ALT levels according to the rs738409 genotypes were available in 11 studies.(1,2,5,6,15,17-21,24) Genotyping for rs738409 was carried out across studies usi”
• Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management. (2015, background): “This variability is in part due to subtle individual genetic differences that modify response to environmental factors and lifestyle, and so determine disease phenotype [14–16].”
• The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent (2016, neutral): “Both PNPLA3 and TM6SF2 variants were found to increase the susceptibility to NAFLD 12-14 .”