WNT signals are required for the initiation of hair follicle development.

By T. Andl, Seshamma T. Reddy, T. Gaddapara, S. Millar. Developmental Cell, 2002

1,079 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Urology

View Paper: https://www.semanticscholar.org/paper/b4d0aed80933d5d9044609a9f20e2a8062d39c61

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In Cell Biology

1. C. Blanpain
2. Elaine Fuchs
3. Jane E. Visvader
4. V. Horsley
5. Hans Clevers
6. R. Nusse
7. Irving L. Weissman
8. Christof Niehrs

In Molecular Biology

1. Hans Clevers
2. Elaine Fuchs
3. C. Blanpain
4. R. Nusse
5. V. Horsley
6. Jane E. Visvader
7. S. Angers
8. Christof Niehrs

In Urology

1. Elaine Fuchs
2. C. Blanpain
3. V. Horsley
4. Hans Clevers
5. R. Nusse
6. H. Pasolli

Citations in the corpus

• Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “BlockingWnt signaling by overexpression of Dkk eliminates hair follicles and other skin appendages, such as the mammary gland (Andl et al., 2002).”
• Epithelial stem cells: turning over new leaves. (2007, positive): “Similarly, overexpression of Dkk1, a soluble inhibitor of Wnt ligands, results in the loss of intestinal crypts (Pinto et al., 2003) and a failure to develop hair-follicle and mammary glands (Andl et al., 2002;Chu et al., 2004).”
• Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “A similar block in HF morphogenesis occurs following the overexpression of the soluble Wnt inhibitor Dickopff-related protein 1 ( DKK1”
• Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “Indeed, transgenic mice overexpressing Dkk1 in the skin are almost hairless, because of inhibition of follicle formation (Andl et al., 2002).”
• Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation (2007, background): “K14 has previously been shown to be expressed in the mammary primordia (placodes”
• Epidermal stem cells of the skin. (2006, background): “Mice expressing a constitutively stabilized β-catenin ( Nβ-catenin) display de novo HFs (Gat et al. 1998) (Figure 4c), whereas mice lacking Lef1 (van Genderen et al. 1994) or β-catenin (Huelsken et al. 2001) or overexpressing the Wnt inhibitor Dkk1 exhibit a paucity of follicles (Andl et al. 2002).”
• Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. (2004, background): “In mutant mice, tooth development is inhibited when the Wnt pathway is blocked by inactivating Lef1 function or by overexpressing the Wnt inhibitor Dkk (van Genderen et al. 1994; Andl et al. 2002).”
• Wnt signaling in development and tissue homeostasis (2018, background): “…of Wnt-β -catenin in hair follicle cycling was identified through the observations that loss of epidermal β -catenin or inhibition of LRP5/6 via ectopic DKK1 expression leads to defects in hair follicle development and/or loss after a single hair cycle (Andl et al., 2002; Huelsken et al., 2001).”
• Therapeutic implications of cancer stem cells. (2004, background): “Additional studies implicate the Wnt/b-catenin pathway in the maintenance of stem-cell self-renewal in other tissues as well [11,12].”
• Wnt-β-catenin signaling initiates taste papilla development (2007, background): “Likewise, genetic deletion of epithelial β-catenin or inhibition of Wnt-β-catenin signaling by ectopic dickkopf1 ( Dkk1”
• Characterization and isolation of stem cell-enriched human hair follicle bulge cells. (2005, background): “The WNT signaling pathway plays an important role in hair follicle morphogenesis and cycling (2, 31), being activated at anagen onset (32, 33).”