Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

By Marie-Liesse Asselin-Labat, K. Sutherland, H. Barker, Richard M Thomas, Mark Shackleton, N. Forrest, L. Hartley, L. Robb, Frank G. Grosveld, J. Wees and 2 more. Nature Cell Biology, 2007

840 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/cf5c1571cb0107065960b4d1f253f6473222302e

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Citations in the corpus

Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery (2009, background): “The luminal subtype included all ERpositive cell lines, and associated gene expression patterns reflected both ER and luminal differentiation pathways, the latter including GATA3 and FOXA1, key transcriptional mediators of luminal differentiation [28,76].”
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors (2007, background): “Taken together, these data suggest that the human 'luminal' profile may actually be a combination of at least two profiles, one of which is ER-regulated and another of which is GATA3-regulated; support for a link between GATA3 and luminal cell origins comes from GATA3 loss studies in mice where the ”
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. (2009, background): “…progenitor populations in mammary epithelium Progenitor cells committed to a luminal cell fate have been identified in the mouse mammary gland on the basis of CD61 (b3 integrin) expression, and negligible or low levels of CD133 (prominin-1) and Sca1 (Asselin-Labat et al. 2007; Sleeman et al. 2007).”
Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State (2012, methodology): “To begin, we used the CD49f and CD61 cell surface antigen markers and fluorescence-activated cell sorting (FACS) to resolve distinct subpopulations of freshly isolated murine MECs; this allowed us to separate murine MECs into three subpopulations as effectively as the published CD29 and CD61 method ”
Integrins in cancer: biological implications and therapeutic opportunities (2010, neutral): “In particular, the integrin αvβ3 represents a marker of luminal progenitor cells in the mammary ductal epitheliu”
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers (2009, methodology): “Two subpopulations show clonogenic activity in vitro To further characterize the epithelial subpopulations, we evaluated progenitor activity with colony-forming cell assays in Matrige”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “GATA3 is required for mammary gland development (Asselin-Labat et al. 2007) and maintains cellular differentiation in the adult (Kouros-Mehr et al.”
Dynamic interplay between the collagen scaffold and tumor evolution (2010, background): “Integrin αvβ3 is a marker of luminal progenitor cells in the mammary epithelium and β3 integrin (also known as CD61) is also a marker of a cancer stem cell-like population [99,100].”