Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

By Sovan Sarkar, Ethan O. Perlstein, S. Imarisio, S. Pineau, A. Cordenier, R. Maglathlin, J. Webster, T. Lewis, Cahir O'Kane, Stefan Schreiber and 1 more. Nature Chemical Biology, 2007

617 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Epidemiology, Neurology

View Paper: https://www.semanticscholar.org/paper/6f42e04ba583311087f26c47c1b099d5f040b221

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Epidemiology

In Neurology

Citations in the corpus

Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “improves clearance of the aggregated proteins and reduces the symptoms of neurodegeneration [95,141].”
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains (2009, methodology): “Third, we used bafilomycin A1, a specific inhibitor of vacuolar H -ATPases and a blocker of autophagosome-lysosome fusion (20, 31).”
Role of autophagy in cancer (2007, neutral): “, and aggregation-prone proteins and protein aggregate”
Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease (2008, background): “…Huntington disease models (Rubinsztein et al., 2005), pharmacologically enhancing the sequestration of misfolded proteins would be expected to promote more rapid digestion and clearance of toxic protein with therapeutic benefits, as has been observed (Ravikumar et al., 2004; Sarkar et al., 2007).”
Autophagy and the integrated stress response (2010, positive): “This mechanism may explain how agents that cause a reduction of IP3 levels cause autophagy in an mTOR-independent fashion (Sarkar et al., 2007).”
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “Trehalose, a widely studied autophagy inducer in neurodegeneration models (Sarkar et al., 2007), has recently been characterized as acting via AMPK activation (DeBosch et al., 2016).”
Human Disease-Drug Network Based on Genomic Expression Profiles (2009, background): “A number of drugs for the treatment of Migraine and Hypertension have been able to stimulate autophagy in fruit flies and zebrafish [40], and therefore are potentially drug candidates for Huntington’s.”