Ferroptosis: mechanisms and links with diseases

By Hong-fa Yan, Ting Zou, Qing-zhang Tuo, Shuo Xu, Hua Li, A. Belaidi, P. Lei. Signal Transduction and Targeted Therapy, 2021

1,270 citations recorded by the source corpus.

Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by the accumulation of lethal lipid species derived from the peroxidation of lipids, which can be prevented by iron chelators (e.g., deferiprone, deferoxamine) and small lipophilic antioxidants (e.g., ferrostatin, liproxstatin). This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association with several pathways, including iron, lipid, and cysteine metabolism. We have further discussed the contribution of ferroptosis to the pathogenesis of several diseases such as cancer, ischemia/reperfusion, and various neurodegenerative diseases (e.g., Alzheimer’s disease and Parkinson’s disease), and evaluated the therapeutic applications of ferroptosis inhibitors in clinics.

Subfields: Cancer Research, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/aff6fa7cc930ba249ec49c486c867b571cdeaeae

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In Cancer Research

1. P. Lei
2. Shu-ting Zhang
3. Qing-zhang Tuo

In Pulmonary and Respiratory Medicine

1. P. Lei
2. Shu-ting Zhang
3. Qing-zhang Tuo

Citations in the corpus

• Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “Further studies have shown that ferroptosis and oxytosis share several molecular features and pathways.(190,268) For example, oxidative stress and GSH depletion are typical features of both oxytosis and ferroptosis.”