Persister cells and tolerance to antimicrobials.
By Iris Keren, N. Kaldalu, Amy Spoering, Yipeng Wang, Kim Lewis. FEMS Microbiology Letters, 2004
1,126 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/b4a705a0290550f03e2cd94a282f486cbc61731f
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Citations in the corpus
- Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “Conversely, at late stationary phase, the percentage of persisters increases and reaches a maximum, suggesting the importance of starvation in the genesis of persisters (114).”
- Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli (2004, background): “It is important to stress that persisters are relatively abundant in stationary state and make up 1% of the population, compared to 10 6 to 10 5 in a logarithmic-phase culture (28).”
- Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents (2017, background): “The tolerance phenomenon of persisters has also been linked with programmed cell death (PCD) while the action of antimicrobial compounds leads the cell towards damage but not for complete cell death, which indirectly triggers PCD [35, 37].”
- Physiological heterogeneity in biofilms (2008, background): “Bistability might help to explain the subsets of bacterial cells, called persister cells , that are found in biofilm”
- Persister cells, dormancy and infectious disease (2007, background): “In order to probe whether persisters isolated during the early exponential phase of growth were introduced from a stationary state culture inoculum, or were formed de novo , the culture was kept in early exponential phase by repeated dilution and regrowt”
- Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies (2021, background): “Persister cells are regarded as dormant variants of regular cells [119].”
- Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli (2010, background): “coli, suggesting the presence of specific persister proteins, rather than random noise in expression of nonspecific genes [4].”
- An overview of the antimicrobial resistance mechanisms of bacteria (2018, background): “These persister cells occur at a rate of around 1% in a culture that is in stationary phase [17,18].”
- Staphylococcal biofilms (2018, background): “by limited diffusion or repulsion, and 2) the specific physiology of a biofilm, which limits the efficacy of antibiotics, mainly of those that target active cell processes and which may also include specific subpopulations of resistant cells (“persisters’) (Keren et al. 2004).”