An overview of the antimicrobial resistance mechanisms of bacteria
By W. Reygaert. AIMS Microbiology, 2018
1,463 citations recorded by the source corpus.
Resistance to antimicrobial agents has become a major source of morbidity and mortality worldwide. When antibiotics were first introduced in the 1900's, it was thought that we had won the war against microorganisms. It was soon discovered however, that the microorganisms were capable of developing resistance to any of the drugs that were used. Apparently most pathogenic microorganisms have the capability of developing resistance to at least some antimicrobial agents. The main mechanisms of resistance are: limiting uptake of a drug, modification of a drug target, inactivation of a drug, and active efflux of a drug. These mechanisms may be native to the microorganisms, or acquired from other microorganisms. Understanding more about these mechanisms should hopefully lead to better treatment options for infective diseases, and development of antimicrobial drugs that can withstand the microorganisms attempts to become resistant.
Subfields: Ecology, Molecular Medicine, Pollution
View Paper: https://www.semanticscholar.org/paper/6da99bc8ae39e21bb371a925e3776678ad25fbe7
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Citations in the corpus
- Antimicrobial Resistance: A Growing Serious Threat for Global Public Health (2023, methodology): “Instead, genes for substrate-specific efflux pumps (for example those for chloramphenicol, tetracyclines, and macrolides) are more likely to be found on mobile genetic elements [38,49].”
- Bacterial Antibiotic Resistance: The Most Critical Pathogens (2021, background): “, vancomycin resistance in Escherichia coli and ampicillin, 1st and 2nd generation cephalosporins resistance in Pseudomonas aeruginosa [19,20].”