Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents
By Shriti Singh, S. Singh, I. Chowdhury, Rajesh Singh. Open Microbiology Journal, 2017
633 citations recorded by the source corpus.
A biofilm is a group of microorganisms, that causes health problems for the patients with indwelling medical devices via attachment of cells to the surface matrix. It increases the resistance of a microorganism for antimicrobial agents and developed the human infection. Current strategies are removed or prevent the microbial colonies from the medical devices, which are attached to the surfaces. This will improve the clinical outcomes in favor of the patients suffering from serious infectious diseases. Moreover, the identification and inhibition of genes, which have the major role in biofilm formation, could be the effective approach for health care systems. In a current review article, we are highlighting the biofilm matrix and molecular mechanism of antimicrobial resistance in bacterial biofilms.
Subfields: Endocrinology, Molecular Biology, Periodontics
View Paper: https://www.semanticscholar.org/paper/30c9dded359c61b0fa419a3c83bce2f3c04f6d6a
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In Molecular Biology
Citations in the corpus
- Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action (2019, background): “These include, among others, (1) limited diffusion of drugs through the exopolysaccharide matrix [13], (2) the presence of persister cells, which will allow the repopulation of biofilms following antibiotic treatment [14], and (3) possibility of exchanging antibiotic-resistant genes between organism”
- Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies (2021, background): “Although efflux pumps are active in planktonic bacteria as well, they are upregulated in biofilms leading to multidrug resistance (MDR) [28, 129].”