Staphylococcal biofilms

By M. Otto. Microbiology spectrum, 2018

881 citations recorded by the source corpus.

ABSTRACT Staphylococci, with the leading species Staphylococcus aureus and Staphylococcus epidermidis, are the most frequent causes of infections on indwelling medical devices. The biofilm phenotype that those bacteria adopt during device-associated infection facilitates increased resistance to antibiotics and host immune defenses. This review presents and discusses the molecular mechanisms contributing to staphylococcal biofilm development and their in-vivo importance. Furthermore, it summarizes current strategies for the development of therapeutics against staphylococcal biofilm-associated infection.

Subfields: Infectious Diseases, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dfa87ec2a40054b7161cf05464013c81a1442444