Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

By Tobias Dörr, M. Vulić, Kim Lewis. PLoS Biology, 2010

770 citations recorded by the source corpus.

Persisters are specialized survivor cells that arise in populations of E. coli after antibiotic-mediated DNA damage induces the production of a small membrane-acting peptide TisB, which causes reversible dormancy. The TisB-dependent persisters are tolerant to multiple antibiotics.

Subfields: Genetics, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/f9fe62e80273de7d2df7719b5def90bd7a27f4b4

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Citations in the corpus

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “Subsequent shutdown of cellular processes is thought to be responsible for the observed higher level of persisters (139, 140).”
Toxin-antitoxin systems in bacteria and archaea. (2011, background): “TisB was shown to be involved with the persister phenomenon after treatment with an antibiotic, ciprofloxacin (27).”
Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, neutral): “floxacin-tolerant cells (374), and HipAB, other toxin/antitoxin”
Mechanisms of bacterial persistence during stress and antibiotic exposure (2016, methodology): “Endogenously expressed TisB only affected tolerance to fluoroquinolones, whereas the overexpression of TisB caused multidrug tolerance (41).”
Antibiotic resistance and persistence—Implications for human health and treatment perspectives (2020, positive): “DNA damage is caused by many factors including oxidative stress, UV light exposure and drugs and usually leads to the induction of the SOS response (Dorr et al , 2010; Baharoglu & Mazel, 2014).”
Bacterial Persister Cell Formation and Dormancy (2013, background): “For the TisB/IstR-1 system, the TisB toxin decreases the proton motive force and ATP levels, which causes the cells to become dormant (22).”