Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli

By Iris Keren, Devang T. Shah, Amy Spoering, N. Kaldalu, Kim Lewis. Journal of Bacteriology, 2004

895 citations recorded by the source corpus.

Subfields: Endocrinology, Genetics, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/744fa0cd9795125aecaf774c777411943a8a000c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

In Genetics

In Molecular Medicine

Citations in the corpus

Persister cells, dormancy and infectious disease (2007, methodology): “The first method to isolate persisters was recently reported, based on the simple sedimentation of surviving cells from a culture that had been lysed by treatment with ampicilli”
Mycobacterium tuberculosis: Success through dormancy (2012, background): “In E. coli, a number of TA modules are relevant in dormancy (Keren et al., 2004; Vazquez-Laslop et al., 2006).”
Bistability in bacteria (2006, background): “A further important insight into the nature of the persister state has come from the work of Keren et al. (2004), who devised a procedure for isolating persister cells and showed that the cells preferentially express the genes for toxin–antitoxin modules.”
Toxin-antitoxin systems in bacteria and archaea. (2011, neutral): “HipB antitoxin employs an HTH domain for binding to the HipA-HipB promoter region (8).”
Mechanisms of bacterial persistence during stress and antibiotic exposure (2016, background): “Mutations affecting bacterial persister formation often compromise tolerance to different antibiotics unevenly, which has also been observed with persisters induced by special growth conditions or genetic manipulations (33, 38, 41, 66, 84).”
Metabolite-Enabled Eradication of Bacterial Persisters by Aminoglycosides (2011, neutral): “Given that NADH drives electron transport, this requirement for NADH is not surprising though we found it is not essential for killing under all conditions (Supplementary Figs 18 and 20).”
Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, background): “cosides to act over protein synthesis (373), as well as TisAB, a DNA”
Growth-rate dependent global effects on gene expression in bacteria (2009, background): “Of particular interest here is that HipA can induce persistence when expressed constitutively on a high-copy number plasmid (Korch and Hill, 2006).”
Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents (2017, background): “[33] Keren I, Shah D, Spoering A, Kaldalu N, Lewis K.”
Multimetal resistance and tolerance in microbial biofilms (2007, background): “Studies using this bacterium suggest that persister cells are metabolically quiescent and express several genes that are associated with stress tolerance, such as chaperones, the multiple antibiotic resistance ( marRAB ) regulon and cold-shock protein”
Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, methodology): “Panel C was inspired by a previous report (103).”
Persisters: a distinct physiological state of E. coli (2006, background): “RelE and MazF are mRNA endonucleases that inhibit translation [18-20] and can cause reversible stasis [9].”
Multidrug tolerance of biofilms and persister cells. (2008, methodology): “Expression of RelE, a toxin that causes reversible stasis by inhibiting cleaving mRNA and inhibiting translation, strongly increased tolerance to antibiotics ( Keren et al. 2004b ).”