De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine

By Anna-Pavlina G. Haramis, H. Begthel, Maaike van den Born, J. van Es, Suzanne M. Jonkheer, G. Offerhaus, Hans Clevers. Science, 2004

798 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/b4805a30c4f85dbf347f7d0bfecd7c7af9526f84

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hans Clevers
2. A. Gregorieff
3. W. Birchmeier
4. Linheng Li
5. Alexander van Oudenaarden
6. Chip Stewart
7. T. Xie
8. Michael R. Stratton

In Molecular Biology

1. Hans Clevers
2. W. Birchmeier
3. Linheng Li
4. Alexander van Oudenaarden
5. A. Gregorieff
6. W. Neaves
7. Alexandra Klaus
8. R. Vries

In Pathology and Forensic Medicine

1. W. Birchmeier
2. A. Gregorieff
3. Hans Clevers

Citations in the corpus

• Stem cell niche: structure and function. (2005, background): “Mechanistically, inhibition of Wnt signaling by the BMP signal involves both the PTEN/PI-3k/Akt pathway and Smadmediated transcriptional control (Haramis et al. 2004, He et al. 2004) In summary, Wnt signaling plays a positive role in promoting ISC activation/self-renewal www.annualreviews.org •…”
• Wnt signalling and its impact on development and cancer (2008, background): “Further work has shown that canonical Wnt signalling cooperates with BMP and Notch signalling in the intestinal stem cell niche to control stem cell self-renewa”
• Prospective derivation of a Living Organoid Biobank of colorectal cancer patients (2015, background): “Epidermal growth factor (EGF) signaling is associated with intestinal proliferation (Wong et al., 2012), while transgenic expression of Noggin induces a dramatic increase in crypt numbers (Haramis et al., 2004).”
• Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “Insight into how these defects occur was recently provided by the generation of transgenic mice expressing the BMP inhibitor Noggin in the intestinal epithelium (Haramis et al. 2004) and in mice in which the BMPR1A gene was conditionally deleted in the intestinal epithelium (He et al. 2004).”
• The intestinal crypt, a prototype stem cell compartment. (2013, background): “BMP-2 and -4 ligands are expressed in the mesenchyme of villi (Haramis et al., 2004), whereas BMP inhibitors are expressed in the mesenchyme around crypts (Kosinski et al.”
• BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling (2004, neutral): “Wild-type (9) Polyp (5) Relative increase”
• Normal stem cells and cancer stem cells: the niche matters. (2006, background): “If this balance is disrupted, stem cells may proliferate without restraint, such as when loss of BMP signaling or abnormal activation of Wnt signaling leads to tumorigenesis (14, 37, 45, 52 , 53).”