Wnt signalling and its impact on development and cancer

By Alexandra Klaus, W. Birchmeier. Nature Reviews. Cancer, 2008

1,602 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f44135d951fd87faeee70c1507ead99072ee3b14

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Citations in the corpus

β-Catenin hits chromatin: regulation of Wnt target gene activation (2009, background): “This complex consists of axin , the adenomatous polyposis coli ( APC ) tumour suppressor protein, glycogen synthase kinase 3β ( GSK3β ), casein kinase 1 ( CK1 ) and protein phosphatase 2A ( PP2A”
Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases (2013, neutral): “Investigating this pathway is extremely relevant as Wnt proteins are a family of highly conserved, secreted signaling molecules playing a pivotal role in cellular development and carcinogenesis, with a large percentage (*90%) of colon cancers arising from activating mutations in the Wnt pathway (250”
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, background): “2006; Klaus and Birchmeier, 2008; Logan and Nusse, 2004; Moon et al., 2004).”
Senescence-messaging secretome: SMS-ing cellular stress (2009, background): “Despite the existence of these functional connections, it is as yet unclear to what extent these in vitro findings, and also the dominant role of Wnt signalling in tumorigenesi”
The Metabolic Profile of Tumors Depends on both the Responsible Genetic Lesion and Tissue Type (2012, background): “…and Kinzler, 2004), are well-known regulators of cellular metabolism (reviewed in (Yuneva, 2008); b-catenin, a central player in the Wnt pathway (Klaus and Birchmeier, 2008), regulates genes responsible for glutamine synthesis (Cadoret et al., 2002); and b-catenin activation in mouse liver is…”
Targeting MET in cancer: rationale and progress (2012, background): “Mutation or overexpression of key components of the WNT–β-catenin pathway can cause cance”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, neutral): “Wnt signaling plays central role in tissue development, and aberrations in this evolutionary conserved pathway has been shown to be linked with the development of cancers [183].”
Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. (2010, background): “The Wnt/b-catenin signaling pathway has a crucial role in the embryonic development of all animal species, in the regeneration of tissues in adult organisms and in numerous other processes (reviewed by Cadigan and Nusse 1997; Clevers 2006; Klaus and Birchmeier 2008).”
Mucins in cancer: function, prognosis and therapy (2009, background): “MUC1 thereby integrates the disruption of adherens junctions with the activation of the Wnt pathway, which has been linked to growth and tumorigenesi”
Covalent histone modifications: miswritten, misinterpreted, and miserased in human cancers (2010, background): “Mutations in components of the Wnt–β-catenin pathway lead to oncogenesis in several tissue type”
Wnt signaling in cancer. (2012, background): “Ultimately, the TCF transcription factors that associated with b-catenin completed the understanding of a basic signaling pathway that could account for the potent tumori- genic effects of Wnt (reviewed by Klaus and Birchmeier 2008).”