BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

By Xi C. He, Jiwang Zhang, Wei Tong, O. Tawfik, J. Ross, D. Scoville, Qiang Tian, Xin Zeng, L. Wiedemann, Y. Mishina and 1 more. Nature Genetics, 2004

1,127 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/870f914aa138f25e2e3e9c1036e3e822550ffc31

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In Molecular Biology

1. Hans Clevers
2. Zena Werb
3. V. Plaks
4. Nick Barker
5. Linheng Li
6. J. Massagué
7. Niwen Kong
8. A. Gregorieff

Citations in the corpus

• Epithelial stem cells: turning over new leaves. (2007, neutral): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript formation of the intestinal crypt (Botchkarev et al., 2001; Haramis et al., 2004; He et al., 2004).”
• Stem cell niche: structure and function. (2005, background): “623 Normal Stem Cells and Cancer Stem Cells: Niche-Dependent or Niche-Independent . . . . . . . . . 623 CLOSING REMARKS . . . . . . . . . . . . . 624”
• Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. (2010, neutral): “Multiple markers were published for this cell (He et al., 2004, 2007; Potten et al., 2003).”
• The intestinal crypt, a prototype stem cell compartment. (2013, background): “Similarly, conditional deletion of Bmp Receptor 1A results in hyperproliferative crypts (He et al., 2004).”
• Normal stem cells and cancer stem cells: the niche matters. (2006, background): “Although BMP4 is constantly expressed in the ISC niche, its antagonist Noggin is transiently expressed in stem cells of the intestines and the hair follicle bulge area (37).”
• TGFβ in Cancer (2008, background): “and intestinal epithelia is required for stem cell maintenance but also for progenitor cell differentiation (He et al., 2004; Kobielak et al., 2007).”
• The intestinal stem cell. (2008, background): “Several other markers have been identified for the +4 cells, i.e., phospho-PTEN and phospho-AKT (He et al. 2004), sFRP5 (Gregorieff et al. 2005), Sox4 (Van der Flier et al. 2007), and Dcamkl1 (Giannakis et al. 2006).”
• Alternative Wnt Signaling Activates YAP/TAZ (2015, neutral): “These include WNT5A, DKK1, BMP4, and IGFBP4 (Figure 5E) (Cruciat and Niehrs, 2013; Haramis et al., 2004; He et al., 2004; Kikuchi et al., 2012; van Amerongen, 2012; Zhu et al., 2008).”