The intestinal crypt, a prototype stem cell compartment.

By Hans Clevers. Cell, 2013

1,138 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/fc658e3b33a59f4f5f30483394597d226bc88213

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. S. Angers
2. Z. Steinhart
3. K. Guan
4. R. Singer
5. Hans Clevers
6. R. Nusse
7. Pengfei Lu

In Molecular Biology

1. S. Angers
2. Z. Steinhart
3. A. Senecal
4. Jeetayu Biswas
5. Maria Vera
6. H. Park
7. K. Guan
8. R. Singer

In Oncology

1. S. Angers
2. Z. Steinhart
3. K. Guan
4. Hans Clevers
5. Pengfei Lu

Citations in the corpus

• Single-Cell and Single-Molecule Analysis of Gene Expression Regulation (2016, background): “Tracking of differentially labeled stem cells has resolved the structure, dynamics, and plasticity of the small intestine in time and space, and provided a platform to analyze the expression patterns of individual cells (35).”
• The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength (2014, neutral): “The resulting organoids (‘‘mini-guts’’) recapitulate essentially all aspects of the self-renewing crypt–villus epithelium and can be expanded for years in culture while remaining genetically and phenotypically stable (Sato and Clevers 2013).”
• New developments in goblet cell mucus secretion and function (2015, neutral): “When Notch signaling is blocked by g-secretase inhibition, the Notch cytoplasmic component no longer enters the nucleus, inhibiting transcriptional signaling and shifting differentiation into the secretory pathway.(24) Without further changes in signaling, goblet cells are the default result of this”
• The Hippo signalling pathway and its implications in human health and diseases (2022, background): “194,195 In addition, the self-renewal and regeneration of the intestine are dependent on intestinal stem cells (ISCs), which are positive for leucine-rich repeat-containing GPCR5 (Lgr5) 196 and mainly express YAP.”
• Modeling Development and Disease with Organoids. (2016, background): “The organoids can be passaged weekly at a 1:5 ratio for years and are remarkably stable, both genetically and phenotypically (Sato and Clevers, 2013).”
• Wnt signaling in development and tissue homeostasis (2018, background): “This has been particularly well studied in the adult intestinal epithelium, which turns over fully every 4-5 days and thereby requires balanced stem and progenitor cell self-renewal, proliferation and differentiation (Clevers, 2013).”