Hypoxia-inducible factors and the response to hypoxic stress.

By Amar J. Majmundar, W. Wong, M. C. Simon. Molecules and Cells, 2010

2,330 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/4a8f2b85ea760aabf8244e7f969359fb02966b4f

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Citations in the corpus

Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation (2012, background): “Inactivating SDH and FH mutations cause the accumulation of succinate and fumarate, respectively, which can inhibit 2-oxoglutarate (2-OG)-dependent enzymes, including the EGLN prolyl 4-hydroxylases that mark the hypoxia inducible factor (HIF) transcription factor for polyubiquitylation and proteasom”
Hypoxia-Inducible Factors in Physiology and Medicine (2012, background): “HIFs are also activated by genetic alterations in human cancers, most notably VHL loss of function in clear cell renal carcinoma (Majmundar et al., 2010).”
Transcriptional Regulation by Hypoxia Inducible Factors (2013, background): “This allows the coordinate activation of genes essential in the adaptive response to hypoxia including pathways that decrease the cellular demand for O2 and increase O2 delivery and tissue re-oxygenation (Greer et al., 2012; Majmundar et al., 2010).”
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress (2010, background): “Recent work shows that hypophosphorylated TSC2 is present within the membrane fraction of cells, where it interacts with TSC1 (Cai et al., 2006).”
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy (2012, background): “A principal mechanism by which O2 regulates HIF activity is through proline and asparagine hydroxylation [3, 4].”
Autophagy and the integrated stress response (2010, neutral): “Following its dephosphorylation, FOXO3 translocates into the nucleus (Figure 3A) and upregulates multiple autophagy-related genes such as ULK2, Beclin 1, VPS34, BNIP3 and BNIP3L, ATG12, ATG4B, LC3, and GABARAPL1 (Mammucari et al., 2007).”
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). (2012, background): “Ras activates the mammalian target of rapamycin (mTOR) via the PI3K-Akt-mTOR signaling pathway and mTOR promotes glycolysis through inducing HIFs (34,55-58).”
Regulation of mTORC1 and its impact on gene expression at a glance (2013, background): “HIF1a also helps to resolve hypoxic stress by promoting angiogenesis (reviewed by Majmundar et al., 2010).”
Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “hypoxia response element to induce the expression of the HIF target gene located in the promoter region [22, 23].”
An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma (2016, neutral): “Loss of VHL leads to aberrant accumulation of HIFa despite an adequately oxygenated tissue microenvironment, which in turn results in uncontrolled activation of HIFa target genes that regulate angiogenesis, glycolysis, and apoptosis (Majmundar et al., 2010; Semenza, 2013).”
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases (2011, background): “Another example of a molecule regulating tumour vessel disorganization is the oxygen sensor prolyl hydroxylase domain-containing protein 2 (PHD2; also known as EGLN1”
Basic and therapeutic aspects of angiogenesis. (2011, neutral): “Hypoxia-inducible factors (HIFs) orchestrate adaptive responses of ECs to changes in oxygen tension by controlling gene networks that govern survival, metabolism, and angiogenesis (Fraisl et al., 2009; Majmundar et al., 2010).”
The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, background): “, VHL), activation of oncogenic signaling, and increased ROS levels [52], [55].”
HECT and RING finger families of E3 ubiquitin ligases at a glance (2012, background): “A key mediator of this is the hypoxia-inducible factor (HIF) family of transcription factors that induce transcription of genes involved in bioenergetics, cell growth and angiogenesis (Kaelin and Ratcliffe, 2008; Majmundar et al., 2010).”
Translational regulation of gene expression during conditions of cell stress. (2010, background): “Hypoxia With the notable exceptions of the anaerobic Loricifera, all metazoans require a plentiful supply of oxygen to all their tissues (Danovaro et al., 2010), andmechanisms have evolved to protect cells from reductions in oxygen concentration (Majmundar et al., 2010).”