Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

By Peter Carmeliet, Rakesh K. Jain. Nature reviews. Drug discovery, 2011

1,644 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bd152047f9b93c7918b64823e7a3bfa2012c568c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. B. Larrivée
2. C. Viallard
3. N. Vasudev
4. Andrew R Reynolds
5. Jun Wu
6. O. Farokhzad
7. N. Kamaly
8. N. Bertrand

In Molecular Biology

1. Rakesh K. Jain
2. Jun Wu
3. B. Larrivée
4. C. Viallard
5. N. Bertrand
6. N. Vasudev
7. Andrew R Reynolds
8. N. Kamaly

Citations in the corpus

• Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “The neovasculature sprouting from capillaries is disordered, discontinuous and highly fenestrated [28].”
• Tumor angiogenesis and vascular normalization: alternative therapeutic targets (2017, background): “However, tumor blood vessels are characterized by their immaturity, which impair their functionality [1].”
• Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions (2014, result): “This results in suppression of PDGF-Rb signalling and decreased pericyte coverage in tumours [222] and may explain the observation that, in some experimental systems, inhibition of VEGF signalling leads to increased pericyte coverage of tumour vessels and increased maturation/normalisation of the tu”
• Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “This lack of efficacy could reflect physical limitations related to drug delivery, dictated by either poor vascularization of metastatic nodules or by anatomical locations of target organs (for example, the blood-brain barrier may protect brain metastases from therapeutic agents delivered via the he”
• Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth (2013, neutral): “Pericytes and ECs communicate with each other by direct physical contact and reciprocal paracrine signaling to maintain vessel integrity and function (Franco et al., 2011; Carmeliet and Jain, 2011; Song et al., 2005).”
• Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (2013, background): “of tumors using both direct and indirect antiangiogenesis agents, including metronomic chemotherapy.(5,102,103) Several new insights”