Basic and therapeutic aspects of angiogenesis.

By M. Potente, Holger Gerhardt, Peter Carmeliet. Cell, 2011

2,678 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ee2a8a67094d8d487316c648c5793aeb30002404

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In Cancer Research

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Citations in the corpus

Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “KEY MOLECULES AND SIGNALING PATHWAYS IN TUMOR ANGIOGENESIS Various biomolecules that promote or inhibit angiogenesis constitute a complex and dynamic angiogenic system, including growth factors (such as vascular endothelial growth factor, fibroblast growth factor, transforming growth factor, hepatoc”
VEGF in Signaling and Disease: Beyond Discovery and Development (2019, background): “VEGF gradients induce tip cells and promote the formation of filopodia (De Bock et al., 2013; Eilken and Adams, 2010; Gerhardt et al., 2003; Gerhardt, 2008; Hellström et al., 2007; Potente et al., 2011; Ruhrberg et al., 2002).”
Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth (2014, positive): “Overall, our data suggest that MALAT1 controls the phenotypic switch from migration to proliferation in endothelial cells, a typical aspect of endothelial cell biology.(27) The antiproliferative effect observed after inhibition of MALAT1 is consistent with a profound dysregulation of cell cycle gene”
Vascular Endothelial Cell Biology: An Update (2019, background): “specific capability of the tip- cells occurs via a notch-mediated lateral inhibition mechanism [144,147].”
SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics (2019, background): “They do so to coordinate their fate and behavior from early developmental stages to mature tissues (1–4), in healthy and diseased (5) conditions.”
Consensus guidelines for the use and interpretation of angiogenesis assays (2018, background): “The majority of EC remains quiescent for years [168], but upon exposure to pro-angiogenic stimuli (such as VEGF), they can rapidly switch to a proliferative and migratory state in health and disease.”