Pattern recognition receptors and control of adaptive immunity

By Noah W. Palm, R. Medzhitov. Immunological Reviews, 2009

757 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/98023bf20451e7a801ca9534c0cbed7b08d443d3

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In Immunology

Citations in the corpus

Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “…that recognize specific molecular patterns have been described (e.g., complement, mannose, scavenger, C-type lectin, nucleotide-binding oligomerization domain [Nod]-like [including NALP3 and NOD2], and retinoic acid-inducible gene I [RIG-I]-like helicase receptors) (Palm and Medzhitov, 2009).”
Activation of STING requires palmitoylation at the Golgi (2016, neutral): “Invading pathogens are identiﬁed by pattern recognition receptors in the host cell, which initiates a series of signalling events that leads to the production of type I interferons, proinﬂammatory cytokines and other downstream antiviral proteins 1,2 .”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “The coordination of these signaling pathways orchestrates immune responses, which contain the spread of an initial infection and direct the appropriate adaptive response (8).”
Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery. (2017, neutral): “, phagocytosis, macropinocytosis), which can occur via a variety of cell surface receptors,(22-24) including PRRs that recognize pathogen- and danger-associated molecular patterns (PAMPs and DAMPs, respectively) (Figure 1a).(19) Internalization of antigen and the engagement of PRRs induce DC maturat”
The innate immune DNA sensor cGAS produces a non-canonical cyclic-di-nucleotide that activates human STING (2013, background): “Several families of germ-line- encoded nucleic acid sensors have been described, including the Toll-like receptors and RIG-I-like receptors (Palm and Medz- hitov, 2009; Takeuchi and Akira, 2010).”
Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? (2009, background): “Microrganisms activate the innate immune system through a variety of pattern-recognition receptors (PRRs), such as the membrane Toll-like receptors (TLR), the cytosolic nucleotidebinding domain, and leucine-rich repeat containing (NLR) molecules and RIG-I-like receptors (RLRs) (Kawai and Akira, 2009”