Molecular Cloning and Functional Characterization of Fatty Acyl Desaturase and Elongase cDNAs Involved in the Production of Eicosapentaenoic and Docosahexaenoic Acids from α-Linolenic Acid in…

By N. Hastings, M. Agaba, D. Tocher, Xiaozhong Zheng, C. Dickson, J. Dick, A. Teale. Marine Biotechnology, 2004

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Effects of diets containing vegetable oil on expression of genes involved in highly unsaturated fatty acid biosynthesis in liver of Atlantic salmon (Salmo salar) (2004, background): “Furthermore, the Δ5 desaturase operates at only one step (conversion of 20:4n-3 to 20:5n-3) in the pathway, whereas the elongase can operate at all elongation steps in the pathway (Hastings et al., 2004).”
Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture (2008, background): “separate cDNAs for ∆6 and ∆5 desaturases have been cloned from Atlantic salmon (Hastings et al. 2004; Zheng et al. 2005a), indicating the presence of multiple desaturase”
Elongation of long-chain fatty acids in rabbitfish Siganus canaliculatus: Cloning, functional characterisation and tissue distribution of Elovl5- and Elovl4-like elongases (2012, background): “, 2000) and teleost Elovl5 proteins (Agaba et al., 2004, 2005; Hastings et al., 2005; Morais et al., 2009, 2011; Zheng et al., 2009a; Gregory et al., 2010; Mohd-Yusof et al., 2010), clearly indicating that vertebrate Elovl generally have broad substrate specificity.”