Expanding the effector CD4 T-cell repertoire: the Th17 lineage.

By L. Harrington, Paul R. Mangan, C. Weaver. Current Opinion in Immunology, 2006

669 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/22ffc505b4c2481b34c6561a001a2ac04be210fc

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Citations in the corpus

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “A relatively new effector CD4+ T cell lineage producing IL-17 has recently been recognized (Harrington et al., 2006; Langrish et al., 2005).”
IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance (2007, background): “IL-23, although not involved in Th17 differentiation, plays an important role in maintaining Th17 effector function [3, 4]. Th17 cells are responsible for various organ-related autoimmune diseases [5, 6 ], and both IL-23 and the Th17 pathway correlate with disease severity and immunopathology in di”
The Role of COX-2 in Intestinal Inflammation and Colorectal Cancer (2009, positive): “cells, has been found to have a key role in Crohn’s disease and may alter the notion of this Th1 and Th2 dichotomy in IBD (Harrington et al., 2006; Steinman, 2007).”
The perfect mix: recent progress in adjuvant research (2007, background): “In particular, various CD4 + T H cell subsets have been defined through their cytokine profiles and ability to modulate B cell and CD8 + CTL response”
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 (2007, positive): “The last conclusion has been called into question by the finding that defects in IFN-γ signaling exacerbate autoimmune disease in some mouse model”
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways (2007, background): “Thus, T helper type 1 (T H 1) cells produce interferon-γ (IFN-γ), which is required for control of infection with viruses and other intracellular pathogens; T H 2 cells make interleukin 4 (IL-4), IL-5 and IL-13, which are required for the clearance of helminths and other parasites; and 'T H -17' cel”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “The recently discovered Th17 cells produce IL-17A (IL-17), IL-17F, IL-21, and IL-22 as major cytokines, while Treg cells synthesize IL-10 and TGFβ1 [Bettelli et al., 2008; Chen and O'Shea, 2008; Dong, 2008; Harrington et al., 2006; Park et al., 2005].”
TH17 cells in development: an updated view of their molecular identity and genetic programming (2008, background): “However, interleukin-17 ( IL-17 )-expressing T cells, which are now widely known as T H 17 cells, were proposed two years ago to be a third lineage of T H cell”