The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.
By Rui Benedito, Cristina Roca, I. Sörensen, Susanne Adams, A. Gossler, M. Fruttiger, R. Adams. Cell, 2009
1,101 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3c65fc4fff553329d2632a65da6a342fa7e6fe09
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In Cell Biology
- Peter Carmeliet
- Rakesh K. Jain
- A. Capobianco
- D. Stainier
- Kelly L. Weaver
- Prathibha Ranganathan
- Ralph J. Deberardinis
In Molecular Biology
- Rakesh K. Jain
- Peter Carmeliet
- Holger Gerhardt
- B. Larrivée
- C. Viallard
- D. Stainier
- S. P. Herbert
- Herbert Levine
Citations in the corpus
- Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence (2022, background): “The monoclonal antibody based on the delta-like ligand 4 Notch ligand also showed effectiveness in treating TNBC (Benedito et al., 2009).”
- Molecular mechanisms and clinical applications of angiogenesis (2011, background): “JAGGED1, another NOTCH ligand expressed by stalk cells, promotes tip-cell selection by interfering with the reciprocal DLL4 and NOTCH signalling from the stalk cell to the tip cel”
- Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis (2015, background): “…can be mediated largely by N-J signaling, because many inflammatory factors such as TNF-α , IFN-γ , and IL-6 can increase the production of Jagged and/or decrease that of Delta (177, 188, 189), thereby promoting N-J signaling that can maintain a cluster of cells in a partial EMT phenotype.”
- Role of PFKFB3-driven glycolysis in vessel sprouting. (2013, positive): “We generated PFKFB3 mice and crossed them with VE-cadherin(PAC)Cre mice, an EC-specific Cre-driver line (Benedito et al., 2009), termed PFKFB3 mice.”
- Tumor angiogenesis and vascular normalization: alternative therapeutic targets (2017, background): “JAG1 therefore helps to maintain the phenotype differentiation by preventing Notch signaling in tip cells [13].”
- Notch signalling in solid tumours: a little bit of everything but not all the time (2011, background): “Spatiotemporal regulation of Notch activation during this process is brought about by Fringe protein”
- Molecular control of endothelial cell behaviour during blood vessel morphogenesis (2011, background): “Whereas DLL4-mediated Notch signalling negatively regulates TC selection, SC-restricted expression of another Notch ligand, Jagged 1, promotes TC formation and angiogenesi”