Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

By L. Studer, M. Csete, Sang‐Hun Lee, N. Kabbani, Jean Walikonis, Barbara J. Wold, R. McKay. Journal of Neuroscience, 2000

745 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aec2c9df543d2e69e49ab060af37105ce9a9a9ca

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Citations in the corpus

Cellular and molecular mechanisms of neural repair after stroke: Making waves (2006, background): “In vitro evidence suggests that EPO promotes neuronal differentiation of neural stem cells.(75,76) Pharmacological doses of EPO promote cell division and increased neuronal progenitor cells in the SVZ after stroke.”
Complexity of dopamine metabolism (2013, background): “Firstly, increased oxygen levels induce DA oxidation thus triggering the generation of ROS and secondly, the oxygen level influences TH protein abundance and activity [86,87].”
The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential (2002, methodology): “Fetal neural progenitor cells have been isolated repeatedly from the mesencephalon and have been used in experimental cellreplacement approaches for PD (Ling et al., 1998; Studer et al., 1998; Potter et al., 1999; Studer et al., 2000; Sanchez-Pernaute et al., 2001; Sawamoto et al., 2001).”
Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. (2002, background): “An early association between physiological oxygen levels (Studer et al., 2000).”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “Observations regarding an enhancement in survival and proliferation of NSCs in mild hypoxic conditions have also been made (Chen et al., 2007; Morrison et al., 2000; Pistollato et al., 2007; Studer et al., 2000).”
Hypoxia-inducible factors in stem cells and cancer (2009, positive): “Several lines of study have indicated a potential involvement of low O2 in the maintenance of cell quiescence [41], proliferation [13] and differentiation [14, 16].”
Erythropoietin Regulates the In Vitro and In Vivo Production of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells (2001, background): “The lowered O2-enhanced differentiation of dopaminergic neurons, from FGF-2-expanded neural precursors, was partially mimicked by EPO and partially reduced by an EPO antibody (Studer et al., 2000).”
The role of oxygen availability in embryonic development and stem cell function (2008, background): “By contrast, reducing the levels of O 2 in cultured rat peripheral and central nervous system stem cells from 21% to between 3% and 5% (physiological normoxia for these cells) promotes their differentiation into neurons with specific neurotransmitter phenotype”