Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.

By K. Hochedlinger, Yasuhiro Yamada, C. Beard, R. Jaenisch. Cell, 2005

872 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/aebea2f56826172a289cf9d51ac80f3f683ad013

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Citations in the corpus

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells (2009, background): “To characterize bladder T-ICs at the molecular level, we examined the expression of several oncoproteins (4, 12, 25, 26) that have been implicated in the self-renewal of adult or embryonic stem cells (27–30).”
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. (2008, methodology): “Wetzlar, Germany) and stained with hematoxylin and eosin or antibodies against Oct4 as previously described (Hochedlinger et al., 2005).”
The role of oxygen availability in embryonic development and stem cell function (2008, background): “, and ectopic Oct4 expression promotes epithelial dysplasia in transgenic mic”
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors (2013, methodology): “, 2009) and Rosa26-M2-rtTA (Hochedlinger et al., 2005) transgenic mice were used for H2B-GFP label retention assays.”
The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (2013, neutral): “Similarly, ablation of Sox2 in the osteoblast lineage in vivo using a Collagen (2.3 kb)-driven Cre line results in reduced bone mineral density and bone volume (Basu-Roy et al., 2010), while transgenic overexpression inhibits mature osteoblast function (Holmes et al., 2011).”
HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. (2006, background): “Notably, a recent report demonstrated that ectopic expression of Oct-4 in mice was sufficient to cause epithelial dysplasia, which represents an early stage in the development of carcinomas (Hochedlinger et al. 2005).”
Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. (2005, neutral): “It was recently reported that ectopic expression of Oct3/4 causes dysplasia in epithelial tissues in adult mice associated with increased transcriptional activity of b-catenin (Hochedlinger et al., 2005).”
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. (2008, methodology): “The majority of fibroblasts containing an optimized reverse tetracycline transactivator driven off the constitutively expressed ROSA26 promoter (R26-M2rtTA) (Hochedlinger et al., 2005) that were infected with a GFP-carrying variant of this virus became GFP within 12–24 hr after doxycycline administr”