Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.

By Hitoshi Niwa, Yayoi Toyooka, Daisuke Shimosato, D. Strumpf, Kadue Takahashi, Rika Yagi, J. Rossant. Cell, 2005

1,266 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/66f242397e984009e0ffcf017b35de9908087e3d

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Citations in the corpus

How is pluripotency determined and maintained? (2007, positive): “, 1988), as do ES cells under particular culture conditions (Niwa et al., 2005).”
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative (2007, neutral): “25) included CDX2 and CGB (encoding the beta chain of human chorionic gonadotropin, βHCG ), associated with trophectoderm differentiatio”
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos (2016, positive): “In mouse, the TE and the inner cell mass (ICM) segregate first, and this is controlled by the opposing transcription factors caudal type homeobox 2 (CDX2) and POU domain class 5 transcription factor 1 (POU5F1, also known as OCTCT3/4) (Niwa et al., 2005).”
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment (2007, positive): “These properties make ES cells a unique system in which to study developmental decisions and differentiation (Kouskoff et al., 2005; Nishikawa et al., 1998; Niwa et al., 2005; Smith, 2001a; Tada et al., 2005), and also a promising tool for biotechnological and biomedical applications (Keller, 2005).”
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. (2009, positive): “To establish Cdx2 / ES cells stably expressing Tead4VP16ER (CTVER5 and CTVER20), dko23-5 ES cells (Niwa et al., 2005) were electroporated with linearized pCAG-Tead4VP16ERIP and selected with 1 mg/ml puromycin in ES cell medium containing 10 mg/ ml blasticidin S and 200 mg/ml G418.”
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells (2007, neutral): “Reduction of Oct3/4 expression below 50% of normal levels induces differentiation of ES cells into trophectoderm by upregulating the transcription factors Cdx2 and Eomesodermin (Eomes)”
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse (2009, positive): “The expression of Cdx2 in ES cells induces them to differentiate into trophoblast, and to acquire the properties of TS cells (Niwa et al., 2005).”
Capture of authentic embryonic stem cells from rat blastocysts. (2008, positive): “Concurrent with downregulation of Oct4 we noted ectopic appearance of Cdx2, the trophectoderm determinant and antagonist of Oct4 (Niwa et al., 2005).”
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes (2013, positive): “To test this idea, we reduced the levels of Oct4 transcription using shRNAs, which leads to activation of the trophectoderm master transcription factor Cdx2 and cellular differentiation (Figure 3C)(Deb et al., 2006; Niwa et al., 2005; Strumpf et al., 2005).”
Epigenetic reprogramming and induced pluripotency (2009, positive): “For instance, the ectopic expression of the transcription factor Cdx2 in ES cells results in the formation of trophectodermal stem cells from ES cells (Niwa et al., 2005).”