Faculty Opinions recommendation of Talin binding to integrin beta tails: a final common step in integrin activation.

By Kenneth M. Yamada. 2003

367 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ae84525ecbd3021c754e926c38082f3159fec982

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Citations in the corpus

An Essential Role for Talin during αMβ2-mediated Phagocytosis (2007, methodology): “976 © 2007 by The American Society for Cell Biology receptors (Tadokoro et al., 2003), and to support the assembly of signaling complexes (Calderwood and Ginsberg, 2003; Nayal et al., 2004; Tanentzapf et al., 2006).”
Synergistic control of cell adhesion by integrins and syndecans (2007, background): “Integrin conformation is influenced by the associations of both the extracellular and the cytoplasmic domains, and cytoplasmic signals that lead to integrin activation from inside the cell (inside–out signalling) seem to converge on talin, as demonstrated by RNAi knockdow”
Platelet-neutrophil-interactions: linking hemostasis and inflammation. (2007, background): “6 The activation and presentation of the ligand binding site of GPIIb/IIIa is initiated by placing the head domain of the intracellular talin molecule between the alpha- and beta-chains.(7) This causes a change of conformation in the extracellular domains, followed by ligand binding, which causes fu”
Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. (2011, background): “The progression from the rather unstable nascent adhesions to dot-like focal complexes upon recruitment of vinculin leads to the formation of larger focal adhesion assembly and the conformational transition of the entire a–b integrin dimers to their active state capable of high-affinity interactions”
Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3 (2006, background): “Rap1-Mediated Integrin Activation Requires Talin Previous work implicated both talin and Rap1 in integrin activation [8, 22]; however, their relationship to each other has remained uncertain.”
Structural basis of integrin activation by talin. (2007, background): “We note, however, that while breaking this salt bridge seems to be necessary, it is not sufficient for full activation (Figure 3A; Tadokoro et al., 2003).”
Integrins (2009, background): “Talin 1–2 and kindlins 1–3 seem to act synergistically to activate integrins by binding to integrin β subunit tails (Larjava et al. 2008; Senetar et al. 2007; Tadokoro et al. 2003), whereas filamin A negatively regulates activation (Kiema et al.”
Focal adhesion regulation of cell behavior. (2004, background): “Talin, a key component of focal adhesions, has emerged as an important regulator of inside-out integrin activation [96–98].”
Extracellular matrix dynamics in development and regenerative medicine (2008, background): “Binding of the cytoplasmic actin-binding protein talin to the integrin 1 tail is crucial for conformational changes that activate the extracellular domain (Tadokoro et al., 2003).”
Activation of a vinculin‐binding site in the talin rod involves rearrangement of a five‐helix bundle (2004, background): “…(Brown et al, 2002) and mouse (Monkley et al, 2000) confirm that talin is essential for integrin-mediated developmental events and (v) talin activates integrins (Tadokoro et al, 2003) by disrupting the interaction between the ab-subunit cytodomains (Vinogradova et al, 2002; Kim et al, 2003).”
Regulation of actin assembly associated with protrusion and adhesion in cell migration. (2008, background): “The role of talin is not only to link the cytoplasmic tail of -integrins to the actin cytoskeleton but also to increase the affinity of the extracellular domain of integrin for the extracellular matrix (220, 222).”
Spleen Tyrosine Kinase Syk Is Necessary for E-Selectin-Induced αLβ2 Integrin-Mediated Rolling on Intercellular Adhesion Molecule-1 (2007, background): “Downstream molecules that have been implicated in integrin activation include p38 MAPK (Simon et al., 2000), ERM proteins (Urzainqui et al., 2002), and talin (Tadokoro et al., 2003).”